BACKGROUND: The aim of this study is to evaluate carcinogens and occupations suspected to cause lung cancer and to generate new hypotheses about occupational risks. METHODS: In a hospital-based study 1004 incident lung cancer cases and the same number of population controls matched for region, sex and age were interviewed between 1988 and 1993 for their smoking and occupational history. Exposure assessment was based on 33 job-specific supplementary questionnaires. Conditional logistic regression was used to calculate odds ratios (OR) and to control for smoking and occupational asbestos exposure. RESULTS: Lifelong prevalence of exposure to asbestos was 20.5% for exposure of more than 940 lifetime working hours among controls, corresponding to an OR of 1.62 (95% confidence interval [CI] : 1.28-2.05) that was reduced to 1.45 after adjustment for smoking (P < 5%). Statistically elevated risks after adjustment for smoking and asbestos were seen in metal production and processing workers, transportation workers and freight handlers, in the rubber and plastics industry, in metal production, in engine and vehicle building, and installation. Significantly increased OR after adjustment for smoking and asbestos that deserve further attention were seen in plastics processing workers (OR = 3.49), and sheet and structural metal workers (OR = 2.01 and 2.37, respectively). CONCLUSIONS: The results of the study confirm previously described occupational risks. Because of the possibility of controlling for occupational asbestos exposure, the study gives clear indications for prevention and further research.
BACKGROUND: The aim of this study is to evaluate carcinogens and occupations suspected to cause lung cancer and to generate new hypotheses about occupational risks. METHODS: In a hospital-based study 1004 incident lung cancer cases and the same number of population controls matched for region, sex and age were interviewed between 1988 and 1993 for their smoking and occupational history. Exposure assessment was based on 33 job-specific supplementary questionnaires. Conditional logistic regression was used to calculate odds ratios (OR) and to control for smoking and occupational asbestos exposure. RESULTS: Lifelong prevalence of exposure to asbestos was 20.5% for exposure of more than 940 lifetime working hours among controls, corresponding to an OR of 1.62 (95% confidence interval [CI] : 1.28-2.05) that was reduced to 1.45 after adjustment for smoking (P < 5%). Statistically elevated risks after adjustment for smoking and asbestos were seen in metal production and processing workers, transportation workers and freight handlers, in the rubber and plastics industry, in metal production, in engine and vehicle building, and installation. Significantly increased OR after adjustment for smoking and asbestos that deserve further attention were seen in plastics processing workers (OR = 3.49), and sheet and structural metal workers (OR = 2.01 and 2.37, respectively). CONCLUSIONS: The results of the study confirm previously described occupational risks. Because of the possibility of controlling for occupational asbestos exposure, the study gives clear indications for prevention and further research.
Authors: H Dean Hosgood; Robert S Chapman; Hu Wei; Xingzhou He; Linwei Tian; Larry Z Liu; Hong Lai; Lawrence S Engel; Wei Chen; Nathaniel Rothman; Qing Lan Journal: Am J Ind Med Date: 2011-10-10 Impact factor: 2.214
Authors: A Pronk; J Coble; B-T Ji; X-O Shu; N Rothman; G Yang; Y-T Gao; W Zheng; W-H Chow Journal: Occup Environ Med Date: 2009-07-21 Impact factor: 4.402
Authors: Carolina Bigert; Per Gustavsson; Kurt Straif; Dirk Taeger; Beate Pesch; Benjamin Kendzia; Joachim Schüz; Isabelle Stücker; Florence Guida; Irene Brüske; Heinz-Erich Wichmann; Angela C Pesatori; Maria Teresa Landi; Neil Caporaso; Lap Ah Tse; Ignatius Tak-Sun Yu; Jack Siemiatycki; Jérôme Lavoué; Lorenzo Richiardi; Dario Mirabelli; Lorenzo Simonato; Karl-Heinz Jöckel; Wolfgang Ahrens; Hermann Pohlabeln; Adonina Tardón; David Zaridze; John K Field; Andrea 't Mannetje; Neil Pearce; John McLaughlin; Paul Demers; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Rodica Stanescu Dumitru; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Paolo Boffetta; Susan Peters; Roel Vermeulen; Hans Kromhout; Thomas Brüning; Ann C Olsson Journal: J Occup Environ Med Date: 2016-11 Impact factor: 2.162
Authors: Sania Amr; Beverly Wolpert; Christopher A Loffredo; Yun-Ling Zheng; Peter G Shields; Raymond Jones; Curtis C Harris Journal: J Occup Environ Med Date: 2008-10 Impact factor: 2.162
Authors: Dario Consonni; Sara De Matteis; Jay H Lubin; Sholom Wacholder; Margaret Tucker; Angela Cecilia Pesatori; Neil E Caporaso; Pier Alberto Bertazzi; Maria Teresa Landi Journal: Am J Epidemiol Date: 2010-01-04 Impact factor: 4.897