OBJECTIVE: This study aimed to determine the safety of deferring radiotherapy in pediatric intracranial ependymoma following a radiographically confirmed gross total resection in patients with localized disease. METHODS: Children over age 3 were recruited prospectively from 1990 to 1997, following a surgical impression and radiologic confirmation of a gross total resection of an intracranial ependymoma. RESULTS: 10/32 cases of intracranial ependymomas were both eligible and gave consent. 7 remain free of disease without further intervention. 3 recurred, 2 were salvaged with surgery and radiotherapy, none died. CONCLUSIONS: Deferral of radiotherapy following gross total resection alone is a safe option in supratentorial ependymomas. The pattern of recurrence is usually local and patients may be salvaged with additional surgery with or without radiotherapy.
OBJECTIVE: This study aimed to determine the safety of deferring radiotherapy in pediatric intracranial ependymoma following a radiographically confirmed gross total resection in patients with localized disease. METHODS:Children over age 3 were recruited prospectively from 1990 to 1997, following a surgical impression and radiologic confirmation of a gross total resection of an intracranial ependymoma. RESULTS: 10/32 cases of intracranial ependymomas were both eligible and gave consent. 7 remain free of disease without further intervention. 3 recurred, 2 were salvaged with surgery and radiotherapy, none died. CONCLUSIONS: Deferral of radiotherapy following gross total resection alone is a safe option in supratentorial ependymomas. The pattern of recurrence is usually local and patients may be salvaged with additional surgery with or without radiotherapy.
Authors: Tamir Ailon; Christopher Dunham; Anne-Sophie Carret; Uri Tabori; P Daniel Mcneely; Shayna Zelcer; Beverley Wilson; Lucie Lafay-Cousin; Donna Johnston; David D Eisenstat; Marianna Silva; Nada Jabado; Karen Jane Goddard; Chris Fryer; Glenda Hendson; Cynthia Hawkins; Sandra Dunn; Stephen Yip; Ashutosh Singhal; Juliette Hukin Journal: Childs Nerv Syst Date: 2014-11-13 Impact factor: 1.475
Authors: Murat Kutlay; Ahmet Cetinkal; Serdar Kaya; Mehmet N Demircan; Murat Velioglu; Ufuk Berber Journal: Childs Nerv Syst Date: 2010-11-26 Impact factor: 1.475
Authors: Daniel M Green; Larry E Kun; Katherine K Matthay; Anna T Meadows; William H Meyer; Paul A Meyers; Sheri L Spunt; Leslie L Robison; Melissa M Hudson Journal: Pediatr Blood Cancer Date: 2013-02-15 Impact factor: 3.167
Authors: Ayal A Aizer; Marek Ancukiewicz; Paul L Nguyen; Shannon M Macdonald; Torunn I Yock; Nancy J Tarbell; Helen A Shih; Jay S Loeffler; Kevin S Oh Journal: J Neurooncol Date: 2013-09-21 Impact factor: 4.130