M Grønbaek1, U Becker, D Johansen, H Tønnesen, G Jensen, T I Sørensen. 1. Copenhagen Centre for Prospective Population Studies, Danish Epidemiology Science Centre at the Institute of Preventive Medicine, Kommunehospitalet, 1399 Copenhagen K, Denmark. mg@ipm.hosp.dk
Abstract
OBJECTIVE: To examine the relation between different types of alcoholic drinks and upper digestive tract cancers (oropharyngeal and oesophageal). DESIGN: Population based study with baseline assessment of intake of beer, wine, and spirits, smoking habits, educational level, and 2-19 years' follow up on risk of upper digestive tract cancer. SETTING: Denmark. SUBJECTS: 15 117 men and 13 063 women aged 20 to 98 years. MAIN OUTCOME MEASURE: Number and time of identification of incident upper digestive tract cancer during follow up. RESULTS: During a mean follow up of 13.5 years, 156 subjects developed upper digestive tract cancer. Compared with non-drinkers (drinkers of <1 drink/week), subjects who drank 7-21 beers or spirits a week but no wine were at a risk of 3.0 (95% confidence interval 1.5 to 6.1), whereas those who had the same total alcohol intake but with wine as >=30% of their intake had a risk of 0.5 (0.2 to 1.4). Drinkers of >21 beers and spirits but no wine had a relative risk of 5.2 (2.7 to 10.2) compared with non-drinkers, whereas those who drank the same amount, but included wine in their alcohol intake, had a relative risk of 1.7 (0.6 to 4. 4). CONCLUSION: A moderate intake of wine probably does not increase the risk of upper digestive tract cancer, whereas a moderate intake of beer or spirits increases the risk considerably.
OBJECTIVE: To examine the relation between different types of alcoholic drinks and upper digestive tract cancers (oropharyngeal and oesophageal). DESIGN: Population based study with baseline assessment of intake of beer, wine, and spirits, smoking habits, educational level, and 2-19 years' follow up on risk of upper digestive tract cancer. SETTING: Denmark. SUBJECTS: 15 117 men and 13 063 women aged 20 to 98 years. MAIN OUTCOME MEASURE: Number and time of identification of incident upper digestive tract cancer during follow up. RESULTS: During a mean follow up of 13.5 years, 156 subjects developed upper digestive tract cancer. Compared with non-drinkers (drinkers of <1 drink/week), subjects who drank 7-21 beers or spirits a week but no wine were at a risk of 3.0 (95% confidence interval 1.5 to 6.1), whereas those who had the same total alcohol intake but with wine as >=30% of their intake had a risk of 0.5 (0.2 to 1.4). Drinkers of >21 beers and spirits but no wine had a relative risk of 5.2 (2.7 to 10.2) compared with non-drinkers, whereas those who drank the same amount, but included wine in their alcohol intake, had a relative risk of 1.7 (0.6 to 4. 4). CONCLUSION: A moderate intake of wine probably does not increase the risk of upper digestive tract cancer, whereas a moderate intake of beer or spirits increases the risk considerably.
Authors: M Jang; L Cai; G O Udeani; K V Slowing; C F Thomas; C W Beecher; H H Fong; N R Farnsworth; A D Kinghorn; R G Mehta; R C Moon; J M Pezzuto Journal: Science Date: 1997-01-10 Impact factor: 47.728
Authors: Mark P Purdue; Mia Hashibe; Julien Berthiller; Carlo La Vecchia; Luigino Dal Maso; Rolando Herrero; Silvia Franceschi; Xavier Castellsague; Qingyi Wei; Erich M Sturgis; Hal Morgenstern; Zuo-Feng Zhang; Fabio Levi; Renato Talamini; Elaine Smith; Joshua Muscat; Philip Lazarus; Stephen M Schwartz; Chu Chen; Jose Eluf Neto; Victor Wünsch-Filho; David Zaridze; Sergio Koifman; Maria Paula Curado; Simone Benhamou; Elena Matos; Neonilia Szeszenia-Dabrowska; Andrew F Olshan; Juan Lence; Ana Menezes; Alexander W Daudt; Ioan Nicolae Mates; Agnieszka Pilarska; Eleonora Fabianova; Peter Rudnai; Debbie Winn; Gilles Ferro; Paul Brennan; Paolo Boffetta; Richard B Hayes Journal: Am J Epidemiol Date: 2008-12-08 Impact factor: 4.897