A Pedersen1, C Johansen, M Grønbaek. 1. Copenhagen Centre for Prospective Population Studies, Danish Epidemiology Science Centre at the Institute of Preventive Medicine, Copenhagen Hospital Corporation, Denmark.
Abstract
BACKGROUND: There may be a weak association between total alcohol intake and colorectal cancer but the effect of different types of alcohol and effect on colon subsites have not been investigated satisfactorily. AIMS: To investigate the relationship between amount and type of alcohol and the risk of colon and rectal cancer. SUBJECTS: A population based cohort study with baseline assessment of weekly intake of beer, wine, and spirits, smoking habits, body mass index, educational level, and leisure time physical activity in Copenhagen, Denmark. The study included a random sample of 15 491 men and 13 641 women, aged 23-95 years. Incident cases of colorectal cancer were identified in the nationwide Danish Cancer Register. RESULTS: During a mean follow up of 14.7 years, we observed 411 colon cancers and 202 rectal cancers. We observed a dose-response relationship between alcohol and rectal cancer. Drinkers of more than 41 drinks a week had a relative risk of rectal cancer of 2.2 (95% confidence limits 1.0-4.6) compared with non-drinkers. Drinkers of more than 14 drinks of beer and spirits a week, but not wine, had a risk of 3.5 (1.8-6.9) of rectal cancer compared with non-drinkers, while those who drank the same amount of alcohol but including more than 30% of wine had a risk of 1.8 (1.0-3.2) of rectal cancer. No relation between alcohol and colon cancer was found when investigating the effects of total alcohol, beer, wine, and spirits, and percentage of wine of total alcohol intake. CONCLUSION: Alcohol intake is associated with a significantly increased risk of rectal cancer but the risk seems to be reduced when wine is included in the alcohol intake.
BACKGROUND: There may be a weak association between total alcohol intake and colorectal cancer but the effect of different types of alcohol and effect on colon subsites have not been investigated satisfactorily. AIMS: To investigate the relationship between amount and type of alcohol and the risk of colon and rectal cancer. SUBJECTS: A population based cohort study with baseline assessment of weekly intake of beer, wine, and spirits, smoking habits, body mass index, educational level, and leisure time physical activity in Copenhagen, Denmark. The study included a random sample of 15 491 men and 13 641 women, aged 23-95 years. Incident cases of colorectal cancer were identified in the nationwide Danish Cancer Register. RESULTS: During a mean follow up of 14.7 years, we observed 411 colon cancers and 202 rectal cancers. We observed a dose-response relationship between alcohol and rectal cancer. Drinkers of more than 41 drinks a week had a relative risk of rectal cancer of 2.2 (95% confidence limits 1.0-4.6) compared with non-drinkers. Drinkers of more than 14 drinks of beer and spirits a week, but not wine, had a risk of 3.5 (1.8-6.9) of rectal cancer compared with non-drinkers, while those who drank the same amount of alcohol but including more than 30% of wine had a risk of 1.8 (1.0-3.2) of rectal cancer. No relation between alcohol and colon cancer was found when investigating the effects of total alcohol, beer, wine, and spirits, and percentage of wine of total alcohol intake. CONCLUSION:Alcohol intake is associated with a significantly increased risk of rectal cancer but the risk seems to be reduced when wine is included in the alcohol intake.
Authors: L A Aaltonen; R Salovaara; P Kristo; F Canzian; A Hemminki; P Peltomäki; R B Chadwick; H Kääriäinen; M Eskelinen; H Järvinen; J P Mecklin; A de la Chapelle Journal: N Engl J Med Date: 1998-05-21 Impact factor: 91.245
Authors: S A Glynn; D Albanes; P Pietinen; C C Brown; M Rautalahti; J A Tangrea; P R Taylor; J Virtamo Journal: Cancer Causes Control Date: 1996-03 Impact factor: 2.506
Authors: M Jang; L Cai; G O Udeani; K V Slowing; C F Thomas; C W Beecher; H H Fong; N R Farnsworth; A D Kinghorn; R G Mehta; R C Moon; J M Pezzuto Journal: Science Date: 1997-01-10 Impact factor: 47.728
Authors: A Yokoyama; T Muramatsu; T Ohmori; T Yokoyama; K Okuyama; H Takahashi; Y Hasegawa; S Higuchi; K Maruyama; K Shirakura; H Ishii Journal: Carcinogenesis Date: 1998-08 Impact factor: 4.944
Authors: A W Hsing; J K McLaughlin; W H Chow; L M Schuman; H T Co Chien; G Gridley; E Bjelke; S Wacholder; W J Blot Journal: Int J Cancer Date: 1998-08-12 Impact factor: 7.396
Authors: Tianzuo Zhan; Felix Hahn; Thomas Hielscher; Asmé Bilge; Jürgen Grüger; Jürgen Weers; Johannes Betge; Timo Gaiser; Georg Kähler; Matthias P Ebert; Sebastian Belle Journal: Int J Colorectal Dis Date: 2016-11-28 Impact factor: 2.571
Authors: Seth D Crockett; Millie D Long; Evan S Dellon; Christopher F Martin; Joseph A Galanko; Robert S Sandler Journal: Dis Colon Rectum Date: 2011-07 Impact factor: 4.585
Authors: Adetunji T Toriola; Sudhir Kurl; Jari A Laukanen; Charles Mazengo; Jussi Kauhanen Journal: Eur J Epidemiol Date: 2008-04-12 Impact factor: 8.082