Literature DB >> 9741884

Evaluation of Nigerian traditional medicines: II. Effects of some Nigerian folk remedies on peptic ulcer.

P A Akah1, O E Orisakwe, K S Gamaniel, A Shittu.   

Abstract

Antiulcer activity of four medicinal plants, Diodia sarmentosa (whole plant), Cassia nigricans (leaves), Ficus exasperata (leaves) and Synclisia scabrida (leaves), which are commonly used by the Nigerian traditional healers for the treatment of peptic ulcer were investigated. Acute toxicity tests were also carried out. The results revealed that the four extracts possess significant anti-ulcerogenic properties in a dose-dependent way. They protected rats from aspirin-induced ulcerogenesis, delayed intestinal transit, increased the pH, and decreased both the volume and acidity of gastric secretion. These results correlate with local use of the plants.

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Year:  1998        PMID： 9741884     DOI： 10.1016/s0378-8741(98)00060-9

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  12 in total

1.  Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides.

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Journal:  Parasitol Res       Date:  2007-12-09       Impact factor: 2.289

2.  In vitro activity of extracts and isolated polyphenols from West African medicinal plants against Plasmodium falciparum.

Authors:  Dieudonné Ndjonka; Bärbel Bergmann; Christian Agyare; Flávia M Zimbres; Kai Lüersen; Andreas Hensel; Carsten Wrenger; Eva Liebau
Journal:  Parasitol Res       Date:  2012-04-05       Impact factor: 2.289

3.  Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals.

Authors:  Ramesh L Londonkar; Pramod V Poddar
Journal:  World J Gastrointest Oncol       Date:  2009-10-15

4.  The use of microfluorometric method for activity-guided isolation of antiplasmodial compound from plant extracts.

Authors:  M N Shuaibu; P A Wuyep; T Yanagi; K Hirayama; T Tanaka; I Kouno
Journal:  Parasitol Res       Date:  2008-01-24       Impact factor: 2.289

5.  Antidiarrheal activity of extracts and compound from Trilepisium madagascariense stem bark.

Authors:  Gerald Ngo Teke; Jules-Roger Kuiate; Victor Kueté; Rémy Bertrand Teponno; Léon Azefack Tapondjou; Gerard Vilarem
Journal:  Indian J Pharmacol       Date:  2010-06       Impact factor: 1.200

6.  Antiarthritic and antioxidant effects of the leaf extract of Ficus exasperata P. Beauv. (Moraceae).

Authors:  Wonder M K Abotsi; Eric Woode; George K Ainooson; Ama K Amo-Barimah; Eric Boakye-Gyasi
Journal:  Pharmacognosy Res       Date:  2010-03

7.  Wound-healing Activity of the Aqueous Leaf Extract and Fractions of Ficus exasperata (Moraceae) and its Safety Evaluation on Albino Rats.

Authors:  Victoria Nonyelum Umeh; Emmanuel Emeka Ilodigwe; Daniel Lotanna Ajaghaku; Earnest Oghenesuvwe Erhirhie; Goodies Emuesiri Moke; Peter Achunike Akah
Journal:  J Tradit Complement Med       Date:  2014-10

8.  Evaluation of Antiulcer Properties of Ethanolic and Hot Aqueous Stem Extracts of Synclisia scabrida on Experimentally Induced Ulcer Models in Albino Mice.

Authors:  Tc Onwudiwe; Po Ughachukwu; Pc Unekwe; Jo Ogamba
Journal:  Ann Med Health Sci Res       Date:  2012-07

9.  Antidiarrheal activity of crude methanolic root extract of Idigofera spicata Forssk.(Fabaceae).

Authors:  Eshetie Melese Birru; Assefa Belay Asrie; Getnet Mequanint Adinew; Asegedech Tsegaw
Journal:  BMC Complement Altern Med       Date:  2016-08-05       Impact factor: 3.659

10.  Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata.

Authors:  Saheed Sabiu; Taofeeq Garuba; Taofik Sunmonu; Emmanuel Ajani; Abdulhakeem Sulyman; Ismaila Nurain; Abdulazeez Balogun
Journal:  Toxicol Rep       Date:  2015-01-08
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