Literature DB >> 18066599

Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides.

Mohammed N Shuaibu1, Ponchang T A Wuyep, Tetsuo Yanagi, Kenji Hirayama, Akitoyo Ichinose, Takashi Tanaka, Isao Kouno.   

Abstract

The antitrypanosomal activity of methanolic extracts of Anogeissus leiocarpus and Terminalia avicennoides were evaluated in vitro against four strains of Trypanosoma species with minimum inhibitory concentration (MIC) value range of 12.5-50 mg/ml. Successive fractionations of the two plant extracts in water, butanol and ethyl acetate gave a range of activity (MIC, 20 to > or =50 microg/ml). Activity-guided and chromatographic analysis of butanolic fractions on Sephadex LH-20 column followed by high-performance liquid chromatography, nuclear magnetic resonance analysis and both ultraviolet and thin layer chromatography revealed hydrolysable tannins with a range of activity (MIC, 7.5-27.5 microg/ml or 14-91 microM). Effect of the compounds on fibroblasts did not reveal serious toxicity at moderate concentration but is concentration dependent.

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Year:  2007        PMID： 18066599     DOI： 10.1007/s00436-007-0815-1

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  26 in total

1.  Induction of apoptosis by hydrolyzable tannins from Eugenia jambos L. on human leukemia cells.

Authors:  L L Yang; C Y Lee; K Y Yen
Journal:  Cancer Lett       Date:  2000-08-31       Impact factor: 8.679

2.  Indigenous knowledge system for treatment of trypanosomiasis in Kaduna state of Nigeria.

Authors:  S E Atawodi; D A Ameh; S Ibrahim; J N Andrew; H C Nzelibe; E O Onyike; K M Anigo; E A Abu; D B James; G C Njoku; A B Sallau
Journal:  J Ethnopharmacol       Date:  2002-02       Impact factor: 4.360

3.  Antiparasitic activities of medicinal plants used in Ivory Coast.

Authors:  T Okpekon; S Yolou; C Gleye; F Roblot; P Loiseau; C Bories; P Grellier; F Frappier; A Laurens; R Hocquemiller
Journal:  J Ethnopharmacol       Date:  2004-01       Impact factor: 4.360

4.  Antibacterial activities of extracts from Nigerian chewing sticks.

Authors:  O Taiwo; H X Xu; S F Lee
Journal:  Phytother Res       Date:  1999-12       Impact factor: 5.878

Review 5.  The evolving role of natural products in drug discovery.

Authors:  Frank E Koehn; Guy T Carter
Journal:  Nat Rev Drug Discov       Date:  2005-03       Impact factor: 84.694

6.  Antibacterial and antifungal activity of traditional medicinal plants used against venereal diseases in South Africa.

Authors:  L V Buwa; J van Staden
Journal:  J Ethnopharmacol       Date:  2005-11-02       Impact factor: 4.360

7.  An ethnobotanical survey of Bauchi State herbal plants and their antimicrobial activity.

Authors:  Harami M Adamu; O J Abayeh; M O Agho; A L Abdullahi; A Uba; H U Dukku; B M Wufem
Journal:  J Ethnopharmacol       Date:  2005-05-13       Impact factor: 4.360

8.  Evaluation of medicinal plants from Mali for their in vitro and in vivo trypanocidal activity.

Authors:  Nsekuye Bizimana; Uwe Tietjen; Karl-Hans Zessin; Drissa Diallo; Coulibaly Djibril; Matthias F Melzig; Peter-Henning Clausen
Journal:  J Ethnopharmacol       Date:  2005-09-26       Impact factor: 4.360

9.  Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei.

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10.  Investigations on antimycobacterial activity of some Ethiopian medicinal plants.

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Journal:  Phytother Res       Date:  2001-06       Impact factor: 5.878
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  14 in total

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Authors:  W R Sawadogo; G Le Douaron; A Maciuk; C Bories; P M Loiseau; B Figadère; I P Guissou; O G Nacoulma
Journal:  Parasitol Res       Date:  2011-10-25       Impact factor: 2.289

2.  Saponins-rich fraction of Calotropis procera leaves elicit no antitrypanosomal activity in a rat model.

Authors:  Mohammed Auwal Ibrahim; Abubakar Babando Aliyu; Kayode Meduteni; Isa Yunusa
Journal:  Asian Pac J Trop Biomed       Date:  2013-07

3.  In vivo antitrypanosomal effects of some ethnomedicinal plants from Nupeland of north central Nigeria.

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Journal:  Afr J Tradit Complement Altern Med       Date:  2010-10-02

4.  Evaluation of medicinal plant extracts against blood-sucking parasites.

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5.  Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine.

Authors:  Oyindamola O Abiodun; Grace O Gbotosho; Edith O Ajaiyeoba; Reto Brun; Ayoade M Oduola
Journal:  Parasitol Res       Date:  2011-07-26       Impact factor: 2.289

6.  Castalagin from Anogeissus leiocarpus mediates the killing of Leishmania in vitro.

Authors:  M N Shuaibu; K Pandey; P A Wuyep; T Yanagi; K Hirayama; A Ichinose; T Tanaka; I Kouno
Journal:  Parasitol Res       Date:  2008-08-09       Impact factor: 2.289

Review 7.  Review on medicinal plants and natural compounds as anti-Onchocerca agents.

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Journal:  Parasitol Res       Date:  2018-07-15       Impact factor: 2.289

8.  Endothelium-independent and endothelium-dependent vasorelaxation by a dichloromethane fraction from Anogeissus Leiocarpus (DC) Guill. Et Perr. (Combretaceae): possible involvement of cyclic nucleotide phosphodiesterase inhibition.

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9.  Differential effectiveness of berry polyphenols as anti-giardial agents.

Authors:  J-P Anthony; L Fyfe; D Stewart; G J McDougall
Journal:  Parasitology       Date:  2011-08       Impact factor: 3.234

10.  Effect of Aqueous Allium cepa and Ixora brachiata Root Extract on Leishmania major Promastigotes.

Authors:  Batool Sadeghi-Nejad; Jasem Saki
Journal:  Jundishapur J Nat Pharm Prod       Date:  2014-04-24
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