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Literature DB >> 974007

The effect of isoprenaline on induction of tumours by methyl nitrosourea in the salivary and mammary glands of female wistar rats.

Abstract

Pretreatment of rats with isoprenaline sulphate (IPR) stimulated DNA synthesis in both salivary and mammary gland tissues. Salivary gland tumours induced by N-methyl-N-nitrosourea (MNU) were observed for the first time in rats, but occurred only in IPR-pretreated animals given MNU during the period of IPR-stimulated DNA synthesis. The cumulative index of MNU-induced mammary tumours and the number of tumours per tumour-bearing rat were increased by IPR-pretreament only if the animals received MNU during the period of IPR-stimulated DNA synthesis.

Entities: Chemical Disease Species

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Year: 1976 PMID： 974007 PMCID： PMC2025246 DOI： 10.1038/bjc.1976.189

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

28 in total

1. Increased susceptibility to low doses of a carcinogen of epidermal cells in stimulated DNA synthesis.

Authors: J V Frei; T Harsono
Journal: Cancer Res Date: 1967-08 Impact factor: 12.701

2. Circadian rhythms in mitotic activity and 3 H-thymidine uptake in the duodenum: effect of isoproterenol on the mitotic rhythm.

Authors: L E Scheving; E R Burns; J E Pauly
Journal: Am J Anat Date: 1972-11

3. Induction of DNA synthesis by a purified chemical compound.

Authors: R Baserga
Journal: Fed Proc Date: 1970 Jul-Aug

4. Incidence of induced tumors in the rat submandibular gland with different doses of 7,12-dimethylbenz-(alpha)-anthracene.

Authors: J A Schmutz; A P Chaudhry
Journal: J Dent Res Date: 1969 Nov-Dec Impact factor: 6.116

5. The rate of breakdown of methyl methanesulphonate, dimethyl sulphate and N-methyl-N-nitrosourea in the rat.

Authors: P F Swann
Journal: Biochem J Date: 1968-11 Impact factor: 3.857

6. Tumours in the mammary gland induced in Lewis rats by intravenous methylnitrosurea.

Authors: G T Bots; R G Willighagen
Journal: Br J Cancer Date: 1975-03 Impact factor: 7.640

7. The effect of sex and of sex and thyroid hormones on the induction of cancers in the salivary glands of rats.

Authors: A Glucksman; C P Cherry
Journal: Br J Cancer Date: 1966-12 Impact factor: 7.640

8. The induction of tumours in the rat by a single oral dose of N-nitrosomethylurea.

Authors: D D Leaver; P F Swann; P N Magee
Journal: Br J Cancer Date: 1969-03 Impact factor: 7.640

9. The histogenesis of carcinomas and sarcomas induced in the salivary glands of rats.

Authors: C P Cherry; A Glücksmann
Journal: Br J Cancer Date: 1965-12 Impact factor: 7.640

10. An autoradiographic study of the early effects of 7,12-dimethylbenz(a)anthracene and progesterone on DNA synthesis in rat mammary epithelial cells and subsequent tumour development.

Authors: A G Jabara; P H Toyne; R J Fisher
Journal: Br J Cancer Date: 1972-08 Impact factor: 7.640

3 in total