Literature DB >> 580763

Different tumours induced by benzo(a)pyrene and its 7,8-dihydrodiol injected into adult mouse salivary gland.

C B Wigley, J Amos, P Brookes.   

Abstract

A comparison has been made between the carcinogenic activities of benzo(a)pyrene and the proposed proximate carcinogen, benzo(a)pyrene 7,8-dihydrodiol, in the adult C57BL mouse submandibular salivary gland. In preliminary studies using a range of doses, the dihydrodiol was slightly less active than the parent hydrocarbon in this system. There was a difference in the type of tumour induced by the 2 compounds. Benzo(a)pyrene induced tumours of the salivary glands at the site of injection, whereas the dihydrodiol induced malignant lymphosarcomas, particularly of the thymus, which were often metastatic to other orgnas. Possible reasons for the different sites of action of the 2 compounds are discussed.

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Year:  1978        PMID： 580763      PMCID： PMC2009623          DOI： 10.1038/bjc.1978.103

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  23 in total

1.  The reaction of 7,8-dihydro-7,8-dihydroxybenzo (a) pyrene-9,10-oxide with DNA in relation to the benzo (a) pyrene-DNA products isolated from cells.

Authors:  M R Osborne; M H Thompson; E M Tarmy; F A Beland; R G Harvey; P Brookes
Journal:  Chem Biol Interact       Date:  1976-06       Impact factor: 5.192

2.  Skin-tumor-initiating ability of benzo(a)pyrene-7,8-diol-9,10-epoxide (anti) when applied topically in tetrahydrofuran.

Authors:  T J Slaga; A Viaje; W M Bracken; D L Berry; S M Fischer; D R Miller; S M Leclerc
Journal:  Cancer Lett       Date:  1977-07       Impact factor: 8.679

3.  Marked differences in the tumor-initiating activity of optically pure (+)- and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene on mouse skin.

Authors:  W Levin; A W Wood; R L Chang; T J Slaga; H Yagi; D M Jerina; A H Conney
Journal:  Cancer Res       Date:  1977-08       Impact factor: 12.701

4.  The nature of benzo[alpha]pyrene binding to DNA in an epithelial cell culture system.

Authors:  C B Wigley; M H Thompson; P Brookes
Journal:  Eur J Cancer       Date:  1976-09       Impact factor: 9.162

5.  Benzo[a]pyrene 7,8-dihydrodiol is more carcinogenic than benzo[a]pyrene in newborn mice.

Authors:  J Kapitulnik; W Levin; A H Conney; H Yagi; D M Jerina
Journal:  Nature       Date:  1977-03-24       Impact factor: 49.962

6.  The target cell in the chemical induction of carcinomas in mouse submandibular gland.

Authors:  C B Wigley; A W Carbonell
Journal:  Eur J Cancer       Date:  1976-09       Impact factor: 9.162

7.  Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,5- and 7,8-diol-9,10-epoxides and 7,8-diol.

Authors:  T J Slaga; A Viaje; D L Betty; W Brachen; S G Buty; J D Scribner
Journal:  Cancer Lett       Date:  1976-11       Impact factor: 8.679

8.  Cell-mediated mutagenesis in cultured Chinese hamster cells by carcinogenic polycyclic hydrocarbons: nature and extent of the associated hydrocarbon-DNA reaction.

Authors:  R F Newbold; C B Wigley; M H Thompson; P Brookes
Journal:  Mutat Res       Date:  1977-04       Impact factor: 2.433

9.  Lifespan, age changes and tumour incidence in an ageing C57BL mouse colony.

Authors:  C Rowlatt; F C Chesterman; M U Sheriff
Journal:  Lab Anim       Date:  1976-10       Impact factor: 2.471

10.  The effect of isoprenaline on induction of tumours by methyl nitrosourea in the salivary and mammary glands of female wistar rats.

Authors:  R Parkin; S Neale
Journal:  Br J Cancer       Date:  1976-10       Impact factor: 7.640
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  1 in total

1.  Animal model of human disease. Pleomorphic salivary adenoma. Virally induced pleomorphic salivary adenoma in the CFLP mouse.

Authors:  P J Lamey; J P Waterhouse; M M Ferguson
Journal:  Am J Pathol       Date:  1982-10       Impact factor: 4.307
  1 in total

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