Literature DB >> 9736585

Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives.

K P Holland1, H L Elford, V Bracchi, C G Annis, S M Schuster, D Chakrabarti.   

Abstract

Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.

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Year:  1998        PMID： 9736585      PMCID： PMC105855     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

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Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1990

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Journal:  Annu Rev Biochem       Date:  1979       Impact factor: 23.643

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Journal:  N Engl J Med       Date:  1977-03-03       Impact factor: 91.245

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Journal:  Adv Enzyme Regul       Date:  1980

6.  New ribonucleotide reductase inhibitors with antineoplastic activity.

Authors:  H L Elford; G L Wampler; B van't Riet
Journal:  Cancer Res       Date:  1979-03       Impact factor: 12.701

7.  Synthesis of hydroxy- and amino-substituted benzohydroxamic acids: inhibition of ribonucleotide reductase and antitumor activity.

Authors:  B van't Riet; G L Wampler; H L Elford
Journal:  J Med Chem       Date:  1979-05       Impact factor: 7.446

8.  Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.

Authors:  R E Desjardins; C J Canfield; J D Haynes; J D Chulay
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

9.  Transgenic mouse model of pharmacologic induction of fetal hemoglobin: studies using a new ribonucleotide reductase inhibitor, Didox.

Authors:  B S Pace; H L Elford; G Stamatoyannopoulos
Journal:  Am J Hematol       Date:  1994-02       Impact factor: 10.047

10.  A phase I and pharmacokinetic study of didox administered by 36 hour infusion. The Cancer Research Campaign Phase I/II Clinical Trials Committee.

Authors:  J Carmichael; B M Cantwell; K A Mannix; D Veale; H L Elford; R Blackie; D J Kerr; S B Kaye; A L Harris
Journal:  Br J Cancer       Date:  1990-03       Impact factor: 7.640
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  8 in total

1.  Protein phosphorylation during Plasmodium berghei gametogenesis.

Authors:  Alberto Alonso-Morales; Lorena González-López; Febe Elena Cázares-Raga; Leticia Cortés-Martínez; Jorge Aurelio Torres-Monzón; José Luis Gallegos-Pérez; Mario Henry Rodríguez; Anthony A James; Fidel de la Cruz Hernández-Hernández
Journal:  Exp Parasitol       Date:  2015-05-22       Impact factor: 2.011

Review 2.  Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.

Authors:  Mahmoud H El Kouni
Journal:  Comp Biochem Physiol B Biochem Mol Biol       Date:  2017-07-21       Impact factor: 2.231

3.  Bench scale production of benzohydroxamic acid using acyl transfer activity of amidase from Alcaligenes sp. MTCC 10674.

Authors:  Ravi Kant Bhatia; Shashi Kant Bhatia; Praveen Kumar Mehta; Tek Chand Bhalla
Journal:  J Ind Microbiol Biotechnol       Date:  2012-10-16       Impact factor: 3.346

4.  Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine.

Authors:  Ritu Banerjee; Jun Liu; Wandy Beatty; Lorraine Pelosof; Michael Klemba; Daniel E Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-08       Impact factor: 11.205

5.  Understanding the molecular interactions of different radical scavengers with ribonucleotide reductase M2 (hRRM2) domain: opening the gates and gaining access.

Authors:  Arijit Basu; Barij N Sinha
Journal:  J Comput Aided Mol Des       Date:  2012-05-26       Impact factor: 3.686

6.  Activity of hydroxyurea against Leishmania mexicana.

Authors:  Hugo Martinez-Rojano; Javier Mancilla-Ramirez; Laura Quiñonez-Diaz; Norma Galindo-Sevilla
Journal:  Antimicrob Agents Chemother       Date:  2008-08-11       Impact factor: 5.191

7.  Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells.

Authors:  Philipp Saiko; Geraldine Graser; Benedikt Giessrigl; Marie-Thérèse Steinmann; Heike Schuster; Andreas Lackner; Michael Grusch; Georg Krupitza; Walter Jaeger; Venkateswarlu Somepalli; Trimurtulu Golakoti; Monika Fritzer-Szekeres; Thomas Szekeres
Journal:  Invest New Drugs       Date:  2013-08-14       Impact factor: 3.850

Review 8.  Targeting the Plasmodium falciparum proteome and organelles for potential antimalarial drug candidates.

Authors:  James Abugri; Joseph Ayariga; Samuel Sunyazi Sunwiale; Cletus Adiyaga Wezena; Julien Agyemang Gyamfi; Michael Adu-Frimpong; Godfred Agongo; Julius Tieroyaare Dongdem; Daniel Abugri; Bismarck Dinko
Journal:  Heliyon       Date:  2022-08-24
  8 in total

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