Literature DB >> 9734357

Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.

Y Mo1, B Vaessen, K Johnston, R Marmorstein.   

Abstract

SAP-1 is a member of the Ets transcription factors and cooperates with SRF protein to activate transcription of the c-fos protooncogene. The crystal structures of the conserved ETS domain of SAP-1 bound to DNA sequences from the E74 and c-fos promoters reveal that a set of conserved residues contact a GGA core DNA sequence. Discrimination for sequences outside this core is mediated by DNA contacts from conserved and nonconserved protein residues and sequence-dependent DNA structural properties characteristic of A-form DNA structure. Comparison with the related PU.1/DNA and GABPalpha/beta/DNA complexes provides general insights into DNA discrimination between Ets proteins. Modeling studies of a SAP-1/SRF/DNA complex suggest that SRF may modulate SAP-1 binding to DNA by interacting with its ETS domain.

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Year:  1998        PMID： 9734357     DOI： 10.1016/s1097-2765(00)80130-6

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  40 in total

1.  Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition.

Authors:  D O Cowley; B J Graves
Journal:  Genes Dev       Date:  2000-02-01       Impact factor: 11.361

2.  Mutants of ETS domain PU.1 and GGAA/T recognition: free energies and kinetics.

Authors:  F Pio; N Assa-Munt; J Yguerabide; R A Maki
Journal:  Protein Sci       Date:  1999-10       Impact factor: 6.725

3.  Crystal structure of an mRNA-binding fragment of Moorella thermoacetica elongation factor SelB.

Authors:  M Selmer; X-D Su
Journal:  EMBO J       Date:  2002-08-01       Impact factor: 11.598

4.  Structure of the archaeal translation initiation factor aIF2 beta from Methanobacterium thermoautotrophicum: implications for translation initiation.

Authors:  Pablo Gutiérrez; Michael J Osborne; Nadeem Siddiqui; Jean-François Trempe; Cheryl Arrowsmith; Kalle Gehring
Journal:  Protein Sci       Date:  2004-03       Impact factor: 6.725

5.  Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.

Authors:  T L Goetz; T L Gu; N A Speck; B J Graves
Journal:  Mol Cell Biol       Date:  2000-01       Impact factor: 4.272

6.  Critical role for the Ets transcription factor ELF-1 in the development of tumor angiogenesis.

Authors:  Xuling Huang; Courtney Brown; Weihua Ni; Elizabeth Maynard; Alan C Rigby; Peter Oettgen
Journal:  Blood       Date:  2005-12-13       Impact factor: 22.113

7.  Correlated motions and interactions at the onset of the DNA-induced partial unfolding of Ets-1.

Authors:  Hiqmet Kamberaj; Arjan van der Vaart
Journal:  Biophys J       Date:  2009-02-18       Impact factor: 4.033

Review 8.  Molecular mechanisms of ETS transcription factor-mediated tumorigenesis.

Authors:  Adwitiya Kar; Arthur Gutierrez-Hartmann
Journal:  Crit Rev Biochem Mol Biol       Date:  2013-09-25       Impact factor: 8.250

9.  Highly conserved amino acids in Pax and Ets proteins are required for DNA binding and ternary complex assembly.

Authors:  D Fitzsimmons; R Lutz; W Wheat; H M Chamberlin; J Hagman
Journal:  Nucleic Acids Res       Date:  2001-10-15       Impact factor: 16.971

10.  Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo.

Authors:  Gong-Hong Wei; Gwenael Badis; Michael F Berger; Teemu Kivioja; Kimmo Palin; Martin Enge; Martin Bonke; Arttu Jolma; Markku Varjosalo; Andrew R Gehrke; Jian Yan; Shaheynoor Talukder; Mikko Turunen; Mikko Taipale; Hendrik G Stunnenberg; Esko Ukkonen; Timothy R Hughes; Martha L Bulyk; Jussi Taipale
Journal:  EMBO J       Date:  2010-06-01       Impact factor: 11.598
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