| Literature DB >> 9733885 |
Abstract
The interferon-induced mouse Mx1 protein has intrinsic antiviral activity against orthomyxoviruses, including Thogoto virus. Thus, Mx1(+) A2G mice are apparently resistant to infection following needle- or tick-borne virus challenge. However, tick-borne challenge and, to a lesser degree, injection of virus mixed with tick salivary gland extract resulted in virus transmission to uninfected ticks feeding on the A2G mice. The data indicate that immunomodulatory components in tick saliva can overcome a natural antiviral mechanism.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9733885 PMCID： PMC110214
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103