Literature DB >> 14731745

Mx proteins: GTPases with antiviral activity.

P Staeheli1, F Pitossi, J Pavlovic.   

Abstract

Mx proteins are synthesized in interferon-treated vertebrate cells. They have attracted much attention because some of them can block the multiplication of influenza A virus and certain other negative-stranded RNA viruses. Recently, Mx proteins have been shown to be GTPases with significant homology to dynamins and yeast VPS1, enzymes involved in intracellular protein trafficking. Several biochemical properties of dynamin and VPS1 are similar to those of Mx, promoting new speculation about how Mx proteins might interfere with virus multiplication.

Entities:  

Year:  1993        PMID： 14731745     DOI： 10.1016/0962-8924(93)90055-6

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  37 in total

1.  Alpha interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells.

Authors:  P Monini; F Carlini; M Stürzl; P Rimessi; F Superti; M Franco; G Melucci-Vigo; A Cafaro; D Goletti; C Sgadari; S Butto'; P Leone; C Chiozzini; C Barresi; A Tinari; A Bonaccorsi; M R Capobianchi; M Giuliani; A di Carlo; M Andreoni; G Rezza; B Ensoli
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

2.  A monomeric GTPase-negative MxA mutant with antiviral activity.

Authors:  C Janzen; G Kochs; O Haller
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

3.  Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids.

Authors:  G Kochs; O Haller
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

4.  Bovine and water buffalo Mx2 genes: polymorphism and antiviral activity.

Authors:  H A E Babiker; Y Nakatsu; K Yamada; A Yoneda; A Takada; J Ueda; H Hata; T Watanabe
Journal:  Immunogenetics       Date:  2006-11-21       Impact factor: 2.846

5.  PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator.

Authors:  T Regad; A Saib; V Lallemand-Breitenbach; P P Pandolfi; H de Thé; M K Chelbi-Alix
Journal:  EMBO J       Date:  2001-07-02       Impact factor: 11.598

6.  The myxovirus resistance A (MxA) gene -88G>T single nucleotide polymorphism is associated with prostate cancer.

Authors:  Shanora Glymph; Sanjay Mandal; Ashley Evans Knowell; Fisseha Abebe; Jaideep Chaudhary
Journal:  Infect Genet Evol       Date:  2013-02-22       Impact factor: 3.342

7.  Role of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity.

Authors:  Alexej Dick; Laura Graf; Daniel Olal; Alexander von der Malsburg; Song Gao; Georg Kochs; Oliver Daumke
Journal:  J Biol Chem       Date:  2015-03-31       Impact factor: 5.157

8.  Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes.

Authors:  Georg Kochs; Christian Janzen; Heinz Hohenberg; Otto Haller
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-05       Impact factor: 11.205

9.  Protection from lethal coxsackievirus-induced pancreatitis by expression of gamma interferon.

Authors:  M S Horwitz; T Krahl; C Fine; J Lee; N Sarvetnick
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

10.  Theiler's virus strain-dependent induction of innate immune responses in RAW264.7 macrophages and its influence on viral clearance versus viral persistence.

Authors:  Stephane Steurbaut; Bart Rombaut; Raf Vrijsen
Journal:  J Neurovirol       Date:  2007       Impact factor: 2.643
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