Literature DB >> 9732746

Transcriptional control of the expression of mouse globin genes in myeloma x erythroleukemia cell hybrids.

A Ar-Rushdi1, K B Tan, C M Croce.   

Abstract

Fusions were made between thymidine kinase deficient (TK-) Friend Cells inducible for hemoglobin production, and immunoglobulin-producing, hypoxanthine-guanine phosphoribosyltransferase-deficient (HGPRT-) myeloma cells. Hybrids were selected in hypoxanthine-aminopterin-thymidine (HAT) and identified by isozyme analysis and chromosome counts. All hybrids resembled the myeloma cell line in mode of growth and were immunoglobulin secretors. All hybrids did not express hemoglobin and were uninducible for hemoglobin production with dimethyl sulfoxide (DMSO). Hybridization of genomic globin DNA probes with hybrid-derived nuclear and cytoplasmic mRNAs blotted to nitrocellulose filter indicated that lack of expression of the globin genes in the hybrids was due to lack of transcription.

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Year:  1982        PMID： 9732746     DOI： 10.1007/bf01538674

Source DB:  PubMed          Journal:  Somatic Cell Genet        ISSN： 0098-0366


  11 in total

1.  Molecular cloning of a human immunoglobulin lambda chain variable sequence.

Authors:  Y Tsujimoto; C M Croce
Journal:  Nucleic Acids Res       Date:  1984-11-26       Impact factor: 16.971

2.  Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt.

Authors:  C M Croce; W Thierfelder; J Erikson; K Nishikura; J Finan; G M Lenoir; P C Nowell
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

3.  Translocated c-myc oncogene of Burkitt lymphoma is transcribed in plasma cells and repressed in lymphoblastoid cells.

Authors:  C M Croce; J Erikson; A ar-Rushdi; D Aden; K Nishikura
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

4.  Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription.

Authors:  J Erikson; K Nishikura; A ar-Rushdi; J Finan; B Emanuel; G Lenoir; P C Nowell; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1983-12       Impact factor: 11.205

5.  The structure and nucleotide sequence of the 5' end of the human c-myc oncogene.

Authors:  R Watt; K Nishikura; J Sorrentino; A ar-Rushdi; C M Croce; G Rovera
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

6.  Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human.

Authors:  K Huebner; A ar-Rushdi; C A Griffin; M Isobe; C Kozak; B S Emanuel; L Nagarajan; J L Cleveland; T I Bonner; M D Goldsborough
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

7.  Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

Authors:  Y Tsujimoto; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

8.  Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.

Authors:  J Erikson; C A Griffin; A ar-Rushdi; M Valtieri; J Hoxie; J Finan; B S Emanuel; G Rovera; P C Nowell; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

9.  Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias.

Authors:  L Nagarajan; E Louie; Y Tsujimoto; A ar-Rushdi; K Huebner; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

10.  Transcriptional activation of the translocated c-myc oncogene in burkitt lymphoma.

Authors:  J Erikson; A ar-Rushdi; H L Drwinga; P C Nowell; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205
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