Literature DB >> 6095199

Molecular cloning of a human immunoglobulin lambda chain variable sequence.

Y Tsujimoto, C M Croce.   

Abstract

We have cloned a human V lambda cDNA sequence from an Ig lambda-producing human Burkitt lymphoma cell line (BL2) by taking advantage of a cloned constant region gene as a primer for cDNA synthesis instead of an oligo(dT) primer. The amino acid sequence deduced from the nucleotide sequence of V lambda clones is highly related to that of the NEW V lambda protein of subgroup I. Southern blot hybridization of human DNAs with the V lambda I probe showed at least 12 hybridizing V lambda fragments. These fragments are amplified in K562 cells which derive from a case of chronic myelogenous leukemia and contain an amplified c-abl oncogene and amplified C lambda sequences.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6095199      PMCID： PMC320379          DOI： 10.1093/nar/12.22.8407

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  29 in total

1.  Sequences at the somatic recombination sites of immunoglobulin light-chain genes.

Authors:  H Sakano; K Hüppi; G Heinrich; S Tonegawa
Journal:  Nature       Date:  1979-07-26       Impact factor: 49.962

2.  Sequences of mouse immunoglobulin light chain genes before and after somatic changes.

Authors:  O Bernard; N Hozumi; S Tonegawa
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

3.  A complete immunoglobulin gene is created by somatic recombination.

Authors:  C Brack; M Hirama; R Lenhard-Schuller; S Tonegawa
Journal:  Cell       Date:  1978-09       Impact factor: 41.582

4.  Multiplicity of germline genes specifying a group of related mouse kappa chains with implications for the generation of immunoglobulin diversity.

Authors:  O Valbuena; K B Marcu; M Weigert; R P Perry
Journal:  Nature       Date:  1978 Dec 21-28       Impact factor: 49.962

5.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

6.  Antibody diversity.

Authors:  J G Seidman; A Leder; M Nau; B Norman; P Leder
Journal:  Science       Date:  1978-10-06       Impact factor: 47.728

7.  A new method for sequencing DNA.

Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

8.  Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

Authors:  S Tonegawa; A M Maxam; R Tizard; O Bernard; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

9.  [The complete amino acid sequence of Bence Jones protein New (lambda-type). Subgroups in the variable part of immunoglobulin L-chains of the lambda-type].

Authors:  B Langer; M Steinmetz-Kayne; N Hilschmann
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1968-07

10.  Chromosomal location of the genes for human immunoglobulin heavy chains.

Authors:  C M Croce; M Shander; J Martinis; L Cicurel; G G D'Ancona; T W Dolby; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205
View more
  17 in total

1.  A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation.

Authors:  K A Siminovitch; V Misener; P C Kwong; Q L Song; P P Chen
Journal:  J Clin Invest       Date:  1989-11       Impact factor: 14.808

2.  First genomic sequence of a human Ig variable lambda gene belonging to subgroup I. Functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus.

Authors:  D Alexandre; P Chuchana; F Brockly; A Blancher; G Lefranc; M P Lefranc
Journal:  Nucleic Acids Res       Date:  1989-05-25       Impact factor: 16.971

3.  Cloning and sequencing of a rearranged V lambda gene from a Burkitt's lymphoma cell line expressing kappa light chains.

Authors:  L H Sun; C M Croce; L C Showe
Journal:  Nucleic Acids Res       Date:  1985-07-11       Impact factor: 16.971

4.  Cloning and sequence analysis of an Ig lambda light chain mRNA expressed in the Burkitt's lymphoma cell line EB4.

Authors:  M L Anderson; L Brown; E McKenzie; J E Kellow; B D Young
Journal:  Nucleic Acids Res       Date:  1985-04-25       Impact factor: 16.971

5.  cDNA clones encoding rabbit immunoglobulin lambda chains. Evidence for length variation of the third hypervariable region and for a novel constant region.

Authors:  D J Hayzer; R M Duvoisin; J C Jaton
Journal:  Biochem J       Date:  1987-08-01       Impact factor: 3.857

6.  Characterization of a lymphoblastoid line deleted for lambda immunglobulin genes.

Authors:  C A Hough; B N White; J J Holden
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

7.  Physical location of the human immunoglobulin lambda-like genes, 14.1, 16.1, and 16.2.

Authors:  T R Bauer; H E McDermid; M L Budarf; M L Van Keuren; B B Blomberg
Journal:  Immunogenetics       Date:  1993       Impact factor: 2.846

Review 8.  Human chromosome 22.

Authors:  J C Kaplan; A Aurias; C Julier; M Prieur; M F Szajnert
Journal:  J Med Genet       Date:  1987-02       Impact factor: 6.318

9.  Regional mapping of two human immunoglobulin V lambda genes and analysis of the V lambda locus in chronic myeloid leukaemia.

Authors:  M L Anderson; M H Goyns; A M Geurts van Kessel; B D Young
Journal:  Nucleic Acids Res       Date:  1985-08-26       Impact factor: 16.971

10.  The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments.

Authors:  S R Bauer; K Huebner; M Budarf; J Finan; J Erikson; B S Emanuel; P C Nowell; C M Croce; F Melchers
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.