Literature DB >> 9726434

Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway.

J E Darnell1.   

Abstract

Sharing the Milstein Award with George R. Stark and Ian M. Kerr in the fall of 1997 brought this invitation to record personal reflections on our experiments concerning the mechanisms of action of interferon. Our work and that of the Kerr and Stark laboratories uncovered the Jak-Stat pathway through which signals from cell surface receptors reach genes in the cell nucleus. This review concentrates on that to which I can speak most reliably, that is, experiments done by my young colleagues at Rockefeller University.

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Year:  1998        PMID： 9726434     DOI： 10.1089/jir.1998.18.549

Source DB:  PubMed          Journal:  J Interferon Cytokine Res        ISSN： 1079-9907            Impact factor:   2.607


  36 in total

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