Literature DB >> 971755

Resistance of cold-exposed rats to aflatoxin.

T B Tilak, V Nagarajan, P G Tulpule.   

Abstract

Male rats kept at a temperature of 4 degrees-5 degrees C were refractory to a lethal dose of aflatoxin compared to animals at 20 degrees-21 degrees C which exhibited a high mortality and marked liver damage. It is suggested that this decreased susceptibility is mediated through a stimulated microsomal drug-metabolizing system in cold environment.

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Year:  1976        PMID: 971755     DOI: 10.1007/BF01927613

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  9 in total

1.  EFFECT OF DIETARY PROTEIN ON AFLATOXIN LIVER INJURY IN WEANLING RATS.

Authors:  T V MADHAVAN; C GOPALAN
Journal:  Arch Pathol       Date:  1965-08

Review 2.  Microsomal metabolism as a determinant of aflatoxin toxicity.

Authors:  T B Tilak; V Nagarajan; P G Tulpule
Journal:  Experientia       Date:  1975-08-15

3.  Effect of cold exposure on drug action and hepatic drug metabolism in the rat.

Authors:  G C Fuller; W F Bousquet; T S Miya
Journal:  Toxicol Appl Pharmacol       Date:  1972-09       Impact factor: 4.219

4.  The interaction of cold environment and carbon tetrachloride hepatotoxicity in mice.

Authors:  S E Adam; E Thorpe
Journal:  Br J Exp Pathol       Date:  1970-08

5.  Susceptibility of vitamin A-deficient rats to aflatoxin.

Authors:  G S Reddy; T B Tilak; D Krishnamurthi
Journal:  Food Cosmet Toxicol       Date:  1973-06

6.  Endocrine factors as determinants of the susceptibility of the liver to carcinogenic agents.

Authors:  C M Goodall
Journal:  N Z Med J       Date:  1968-01

7.  Effect of environmental temperature on fatty livers produced by various hepatotoxic agents in rats.

Authors:  M W Radomski; T Orme
Journal:  J Nutr       Date:  1967-05       Impact factor: 4.798

8.  Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity.

Authors:  R O Recknagel; A K Ghoshal
Journal:  Lab Invest       Date:  1966-01       Impact factor: 5.662

9.  Necrogenic action of carbon tetrachloride in the rat: a speculative mechanism based on activation.

Authors:  T F Slater
Journal:  Nature       Date:  1966-01-01       Impact factor: 49.962

  9 in total

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