Literature DB >> 169144

Microsomal metabolism as a determinant of aflatoxin toxicity.

T B Tilak, V Nagarajan, P G Tulpule.   

Abstract

The evidences to incriminate the possible role of microsomal drug metabolizing system in aflatoxin toxicity in rat have been reviewed. It is suggested that an effective drug metabolism results in decreased acute toxicity and the products of metabolism are more carcinogenic than the native toxin to the rat liver.

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Year:  1975        PMID: 169144     DOI: 10.1007/bf02358872

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  28 in total

1.  VARIATION IN THE ACTIVITY OF LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES IN RATS IN RELATION TO THE AGE.

Authors:  R KATO; P VASSANELLI; G FRONTINO; E CHIESARA
Journal:  Biochem Pharmacol       Date:  1964-07       Impact factor: 5.858

2.  EFFECT OF FEEDING AFLATOXIN TO YOUNG MONKEYS.

Authors:  P G TULPULE; T V MADHAVAN; C GOPALAN
Journal:  Lancet       Date:  1964-05-02       Impact factor: 79.321

3.  Cortisone and liver function.

Authors:  K ATERMAN; N D AHMAD
Journal:  Lancet       Date:  1953-01-10       Impact factor: 79.321

4.  Metabolism of aflatoxin in susceptible and resistant animal species.

Authors:  D S Patterson; R Allcroft
Journal:  Food Cosmet Toxicol       Date:  1970-02

5.  Rat colon carcinomas associated with aflatoxin and marginal vitamin A.

Authors:  P M Newberne; A E Rogers
Journal:  J Natl Cancer Inst       Date:  1973-02       Impact factor: 13.506

6.  A metabolic basis for midzonal necrosis of the liver.

Authors:  A A Seawright
Journal:  J Pathol       Date:  1972-07       Impact factor: 7.996

7.  Aflatoxin carcinogenesis: inhibition of liver cancer induction in hypophysectomized rats.

Authors:  C M Goodall; W H Butler
Journal:  Int J Cancer       Date:  1969-07-15       Impact factor: 7.396

Review 8.  The inhibition and mechanism of intestinal absorption.

Authors:  P A Sanford
Journal:  Proc Nutr Soc       Date:  1967       Impact factor: 6.297

9.  Endocrine factors as determinants of the susceptibility of the liver to carcinogenic agents.

Authors:  C M Goodall
Journal:  N Z Med J       Date:  1968-01

10.  Effect of prednisolone on liver damage in rats induced by aflatoxin.

Authors:  T V Madhavan
Journal:  J Pathol Bacteriol       Date:  1967-04
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  2 in total

1.  Resistance of cold-exposed rats to aflatoxin.

Authors:  T B Tilak; V Nagarajan; P G Tulpule
Journal:  Experientia       Date:  1976-09-15

2.  Enzymatic adaptations of herbivorous insects and mites to phytochemicals.

Authors:  S Ahmad
Journal:  J Chem Ecol       Date:  1986-02       Impact factor: 2.626

  2 in total

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