Literature DB >> 971742

The oxidative metabolism of alpha-chlorohydrin and the chemical induction of spermatocoeles.

A R Jones, C Murcott.   

Abstract

alpha-Chlorohydrin (I) is oxidatively metabolized to beta-chlorolactic acid (III) and oxalic acid (IV). Deposition of calcium oxalate within the renal tubules is responsible for the toxic effects of alpha-chlorohydrin and a similar action on the epididymis or epididymal blood vessels could initiate the formation of spermatocoeles from this and other male antifertility agents.

Entities:  

Keywords:  Alcohols; Alpha-chlorohydrin; Animals, Laboratory; Biology; Clinical Research; Contraceptive Agents, Male; Epididymis; Genitalia; Genitalia, Male; Ingredients And Chemicals; Organic Chemicals; Physiology; Research Methodology; Sperm Maturation Blocking Agents; Testis; Urogenital System

Mesh:

Substances:

Year:  1976        PMID: 971742     DOI: 10.1007/BF01927587

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  12 in total

1.  Identification of the biochemical lesion produced by alpha-chlorohydrin in spermatozoa.

Authors:  H Mohri; D A Suter; P D Brown-Woodman; I G White; D D Ridley
Journal:  Nature       Date:  1975-05-01       Impact factor: 49.962

2.  The metabolism of 3-chloro,- 3-bromo- and 3-iodoprpan-1,2-diol in rats and mice.

Authors:  A R Jones
Journal:  Xenobiotica       Date:  1975-03       Impact factor: 1.908

3.  Studies in detoxication. 86. The metabolism of 14C-labelled ethylene glycol.

Authors:  P K GESSNER; D V PARKE; R T WILLIAMS
Journal:  Biochem J       Date:  1961-06       Impact factor: 3.857

4.  Studies in detoxication. XLIX. The metabolism of benzene containing (14C1) benzene.

Authors:  D V PARKE; R T WILLIAMS
Journal:  Biochem J       Date:  1953-05       Impact factor: 3.857

5.  A new orally active male antifertility agent.

Authors:  J A Coppola; R J Saldarini
Journal:  Contraception       Date:  1974-05       Impact factor: 3.375

6.  Effects of alpha-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat.

Authors:  E R Cooper; A R Jones; H Jackson
Journal:  J Reprod Fertil       Date:  1974-06

7.  An extragonadal male antifertility agent.

Authors:  J A Coppola
Journal:  Life Sci       Date:  1969-01-01       Impact factor: 5.037

8.  Male antifertility compounds: U-5897 as a rat chemosterilant.

Authors:  R J Ericsson
Journal:  J Reprod Fertil       Date:  1970-07

9.  Is glycidol an active intermediate in the antifertility action of alpha-chlorhydrin in male rats?

Authors:  H Jackson; I S Campbell; A R Jones
Journal:  Nature       Date:  1970-04-04       Impact factor: 49.962

10.  Antifertility activity of 3-chloro-1, 2-propanediol (U-5897) on male rats.

Authors:  E Samojlik; M C Chang
Journal:  Biol Reprod       Date:  1970-04       Impact factor: 4.285

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  1 in total

1.  The metabolism of the male antifertility agent 1-amino-3-chloropropan-2-ol in the rat.

Authors:  A R Jones; C Murcott; D H Milton; J Flynn
Journal:  Experientia       Date:  1977-07-15
  1 in total

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