Literature DB >> 971735

On the metabolism of prostaglandins by rat brain homogenate.

E E Kröner, B A Peskar.   

Abstract

Using radio-immuno assays for prostaglandins and prostaglandin metabolites, three prostaglandin metabolizing enzymes were found in the 100,000 X g supernatant of rat brain, 15-hydroxy-prostaglandin-dehydrogenase, delta13-reductase and prostaglandin E-9-keto-reductase. Specific activity of the latter enzyme was highest in striatum and midbrain and lowest in cortex, cerebellum and spinal cord.

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Year:  1976        PMID： 971735     DOI： 10.1007/BF01927575

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase.

Authors:  S C Lee; L Levine
Journal:  J Biol Chem       Date:  1975-06-25       Impact factor: 5.157

Review 2.  Prostaglandins and the central nervous system.

Authors:  F Coceani
Journal:  Arch Intern Med       Date:  1974-01

3.  Reduction of prostaglandin E2 to prostaglandin F2alpha by an enzyme in sheep blood.

Authors:  C N Hensby
Journal:  Biochim Biophys Acta       Date:  1974-04-26

4.  Metabolism of prostaglandin E 1 in the cerebral cortex and cerebellum of the dog and rat.

Authors:  J Nakano; A V Prancan; S E Moore
Journal:  Brain Res       Date:  1972-04-28       Impact factor: 3.252

5.  Prostaglandin-norepinephrine interactions in brain: microelectrophoretic and histochemical correlates.

Authors:  G Siggins; B Hoffer; F Bloom
Journal:  Ann N Y Acad Sci       Date:  1971-04-30       Impact factor: 5.691

6.  Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.

Authors:  S C Lee; S S Pong; D Katzen; K Y Wu; L Levine
Journal:  Biochemistry       Date:  1975-01-14       Impact factor: 3.162

7.  Drugs which inhibit prostaglandin biosynthesis.

Authors:  R J Flower
Journal:  Pharmacol Rev       Date:  1974-03       Impact factor: 25.468

8.  The biological activities of three metabolites of prostaglandin E 1.

Authors:  E Anggård
Journal:  Acta Physiol Scand       Date:  1966-04

9.  Stereospecificity of enzymatic reduction of prostaglandin E2 to F2alpha.

Authors:  L Levine; K Y Wu; S S Pong
Journal:  Prostaglandins       Date:  1975-04

10.  Prostaglandin metabolism. I. Cytoplasmic reduced nicotinamide adenine dinucleotide phosphate-dependent and microsomal reduced nicotinamide adenine dinucleotide-dependent prostaglandin E 9-ketoreductase activities in monkey and pigeon tissues.

Authors:  S C Lee; L Levine
Journal:  J Biol Chem       Date:  1974-03-10       Impact factor: 5.157
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  1 in total

Review 1.  Prostaglandin-mediated hypercalcemia: a paraneoplastic syndrome.

Authors:  H W Seyberth
Journal:  Klin Wochenschr       Date:  1978-04-15
  1 in total

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