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Literature DB >> 205705

Prostaglandin-mediated hypercalcemia: a paraneoplastic syndrome.

Abstract

Evidence has been presented for prostaglandin-mediated hypercalcemia and bone resorption in malignancies of both, experimental animals and man. Occurence of hypercalcemia in cancer patients is known for a long time, but its pathogenesis has been poorly understood so far. Besides ectopic parathyroid hormone secretion by tumors, an osteoclast-activating factor released from leukocytes and direct bone destruction by tumor cells, prostaglandins of the E series have to be considered as one of the candicates involved in the pathomechanism of hypercalcemia and osteoclastic osteolysis in cancer patients. This new concept on the pathophysiology of cancer-associated hypercalcemia has implications for the diagnosis and management of this common complication of neoplastic disease.

Entities: Chemical Disease Species

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Year: 1978 PMID： 205705 DOI： 10.1007/bf01477292

Source DB: PubMed Journal: Klin Wochenschr ISSN： 0023-2173

137 in total

1. Prostaglandin: increased production by renal cell carcinoma.

Authors: K B Cummings; R F Wheelis; R P Robertson
Journal: Surg Forum Date: 1975

2. Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins.

Authors: C S Galasko; A Bennett
Journal: Nature Date: 1976-10-07 Impact factor: 49.962

3. Inhibition of prostaglandin synthesis in man.

Authors: M Hamberg
Journal: Biochem Biophys Res Commun Date: 1972-11-01 Impact factor: 3.575

4. Prostaglandin production by mouse fibrosarcoma cells in culture: inhibition by indomethacin and aspirin.

Authors: L Levine; P M Hinkle; E F Voelkel; A H Tashjian
Journal: Biochem Biophys Res Commun Date: 1972-05-26 Impact factor: 3.575

5. Phospholipid precursors of prostaglandins.

Authors: W E Lands; B Samuelsson
Journal: Biochim Biophys Acta Date: 1968-10-22

6. Drugs which inhibit prostaglandin biosynthesis.

Authors: R J Flower
Journal: Pharmacol Rev Date: 1974-03 Impact factor: 25.468

7. Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig.

Authors: R J Gryglewski; B Panczenko; R Korbut; L Grodzinska; A Ocetkiewicz
Journal: Prostaglandins Date: 1975-08

8. Breast-cancer osteolysis, bone metastases, and anti-osteolytic effect of aspirin.

Authors: T J Powles; M Dowsett; G C Easty; D M Easty; A M Neville
Journal: Lancet Date: 1976-03-20 Impact factor: 79.321

9. Rat osteogenic sarcoma cells:effects of some prostaglandins, their metabolites and analogues on cyclic AMP production.

Authors: D Atkins; T J Martin
Journal: Prostaglandins Date: 1977-05

10. Kinetic parameters and renal clearances of plasma adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in man.

Authors: A E Broadus; N I Kaminsky; J G Hardman; E W Sutherland; G W Liddle
Journal: J Clin Invest Date: 1970-12 Impact factor: 14.808

4 in total

1. Effects of 2-aminomethyl-4-t-butyl-6-iodophenol (MK-447) on granulomatous inflammation: lack of correlation with changes in levels of prostaglandin-like material.

Authors: M J Parnham; M J Adolfs; I L Bonta
Journal: Agents Actions Date: 1979-08