Literature DB >> 971732

Synthesis of eel-calcitonin and (asu1,7)-eel-calcitonin: contribution of the disulfide bond to the hormonal activity.

T Morikawa, E Munekata, S Sakakibara, T Noda, M Otani.   

Abstract

Eel-calcitonin and its [asu1,7]-analog, deamino-dicarba-analog, were synthesized by the conventional solution method. The natural-type product showed 4300 MRC U/mg in the hypocalcemic potency which was comparable to that of the natural hormone isolated from eel. Hormonal activity of the Asu-analog was also as high as 3400 MRC U/mg.

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Year:  1976        PMID： 971732     DOI： 10.1007/BF01927568

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  [Structure-activity relationship of human calcitonin. III. Biological activity of synthetic analogues with shortened or terminally modified peptide chains (author's transl)].

Authors:  W Rittel; R Maier; M Brugger; B Kamber; B Riniker; P Sieber
Journal:  Experientia       Date:  1976-02-15

2.  [Synthesis of salmon calcitonin, a high activity hypocalcemic hormone].

Authors:  S Guttmann; J Pless; R L Huguenin; E Sandrin; H Bossert; K Zehnder
Journal:  Helv Chim Acta       Date:  1969       Impact factor: 2.164

3.  Isolation and chemical properties of two calcitonins from salmon ultimobranchial glands.

Authors:  H T Keutmann; J A Parsons; J T Potts; R J Schlueter
Journal:  J Biol Chem       Date:  1970-03-25       Impact factor: 5.157

4.  Amino acid composition of salmon calcitonin.

Authors:  R K O'Dor; C O Parkes; D H Copp
Journal:  Can J Biochem       Date:  1969-08

5.  A new method for releasing oxytocin from fully-protected nona-peptides using anhydrous hydrogen fluoride.

Authors:  S Sakakibara; Y Shimonishi
Journal:  Bull Chem Soc Jpn       Date:  1965-08       Impact factor: 5.488

6.  A biological assay for calcitonin.

Authors:  M A Kumar; E Slack; A Edwards; H A Soliman; A Baghdiantz; G V Foster; I MacIntyre
Journal:  J Endocrinol       Date:  1965-11       Impact factor: 4.286

7.  Amino acid sequence of salmon ultimobranchial calcitonin.

Authors:  H D Niall; H T Keutmann; D H Copp; J T Potts
Journal:  Proc Natl Acad Sci U S A       Date:  1969-10       Impact factor: 11.205
  7 in total
  19 in total

1.  Determination of the bioavailability of intranasal elcatonin in humans: development of a sandwich transfer enzyme immunoassay for elcatonin.

Authors:  T Kohno; N Murasugi; H Sakurai; K Watabe; H Nakamuta; M Koida; Y Sugie; T Ogouchi; T Inoue; M Yanaka; M Nomura; A Yanagawa
Journal:  J Clin Lab Anal       Date:  1998       Impact factor: 2.352

2.  Monoclonal antibodies against calcitonin. Characterization and application in light and electron microscopy immunocytochemistry.

Authors:  L Scopsi; J Arias; G Houen; G Racchetti; G L Fossati; Y M Galante
Journal:  Histochemistry       Date:  1988

Review 3.  Peptides from the calcitonin genes: molecular genetics, structure and function.

Authors:  L H Breimer; I MacIntyre; M Zaidi
Journal:  Biochem J       Date:  1988-10-15       Impact factor: 3.857

4.  Voltage-gated sodium and potassium currents and their variation in calcitonin-secreting cells of the chick.

Authors:  K Kawa
Journal:  J Physiol       Date:  1988-05       Impact factor: 5.182

5.  Effects of combined elcatonin and alendronate treatment on the architecture and strength of bone in ovariectomized rats.

Authors:  Koko Ogawa; Masayuki Hori; Ryoko Takao; Toyozo Sakurada
Journal:  J Bone Miner Metab       Date:  2005       Impact factor: 2.626

6.  A human calcitonin-like molecule in the ultimobranchial body of the amphibia (Rana pipiens).

Authors:  R Perez-Cano; F Galan Galan; S I Girgis; T R Arnett; I MacIntyre
Journal:  Experientia       Date:  1981-10-15

7.  Promotion of calcification by imidazole and its suppression by diltiazem in the growth cartilage of rats with HEBP induced rickets.

Authors:  M Eguchi; H Kawamura; F Wada; T Shimauchi; E Shiota; K Shibata; Y Sugioka
Journal:  Int Orthop       Date:  1989       Impact factor: 3.075

Review 8.  Future horizons for calcitonin: a U.S. perspective.

Authors:  J H Carstens; J D Feinblatt
Journal:  Calcif Tissue Int       Date:  1991       Impact factor: 4.333

9.  Calcitonin treatment for intersternocostoclavicular ossification: clinical experience in two cases.

Authors:  T Misaki; S Dokoh; E Mori
Journal:  Ann Rheum Dis       Date:  1991-11       Impact factor: 19.103

10.  Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis.

Authors:  Jun Iwamoto; Mitsuyoshi Uzawa; Yoshihiro Sato; Tsuyoshi Takeda; Hideo Matsumoto
Journal:  Ther Clin Risk Manag       Date:  2009-07-12       Impact factor: 2.423
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