Literature DB >> 9717254

Pathogenicity island mediates Helicobacter pylori interaction with the host.

R Rappuoli1, C Lange, S Censini, A Covacci.   

Abstract

In Helicobacter pylori, a pathogenicity island (PAI) of approximately 40 kb, named cag, is present in a subset of strains. The strains containing the PAI are more virulent than those that do not contain it, and are associated with peptic ulcer and gastric cancer. A putative secretory mechanism is encoded by this PAI. This secretory system is thought to be involved in the induction of the proiflammatory lymphokine IL-8 and tyrosine phosphorylation of proteins in the gastric cells. We are currently investigating the potential toxic factors exported by this region.

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Year:  1998        PMID： 9717254     DOI： 10.1007/bf02818612

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  14 in total

1.  Induction of host signal transduction pathways by Helicobacter pylori.

Authors:  E D Segal; C Lange; A Covacci; L S Tompkins; S Falkow
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

Review 2.  Adaptation of a conjugal transfer system for the export of pathogenic macromolecules.

Authors:  S C Winans; D L Burns; P J Christie
Journal:  Trends Microbiol       Date:  1996-02       Impact factor: 17.079

Review 3.  Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori?

Authors:  A Covacci; S Falkow; D E Berg; R Rappuoli
Journal:  Trends Microbiol       Date:  1997-05       Impact factor: 17.079

4.  The interrelationship between cytotoxin-associated gene A, vacuolating cytotoxin, and Helicobacter pylori-related diseases.

Authors:  J F Weel; R W van der Hulst; Y Gerrits; P Roorda; M Feller; J Dankert; G N Tytgat; A van der Ende
Journal:  J Infect Dis       Date:  1996-05       Impact factor: 5.226

5.  Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin.

Authors:  Z Xiang; S Censini; P F Bayeli; J L Telford; N Figura; R Rappuoli; A Covacci
Journal:  Infect Immun       Date:  1995-01       Impact factor: 3.441

6.  Pilus assembly by Agrobacterium T-DNA transfer genes.

Authors:  K J Fullner; J C Lara; E W Nester
Journal:  Science       Date:  1996-08-23       Impact factor: 47.728

7.  Induction of interleukin-8 secretion from gastric epithelial cells by a cagA negative isogenic mutant of Helicobacter pylori.

Authors:  J E Crabtree; Z Xiang; I J Lindley; D S Tompkins; R Rappuoli; A Covacci
Journal:  J Clin Pathol       Date:  1995-10       Impact factor: 3.411

8.  Development of a mouse model of Helicobacter pylori infection that mimics human disease.

Authors:  M Marchetti; B Aricò; D Burroni; N Figura; R Rappuoli; P Ghiara
Journal:  Science       Date:  1995-03-17       Impact factor: 47.728

9.  Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer.

Authors:  A Covacci; S Censini; M Bugnoli; R Petracca; D Burroni; G Macchia; A Massone; E Papini; Z Xiang; N Figura
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

10.  Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

Authors:  J L Telford; P Ghiara; M Dell'Orco; M Comanducci; D Burroni; M Bugnoli; M F Tecce; S Censini; A Covacci; Z Xiang
Journal:  J Exp Med       Date:  1994-05-01       Impact factor: 14.307
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  2 in total

1.  Helicobacter pylori resists phagocytosis by macrophages: quantitative assessment by confocal microscopy and fluorescence-activated cell sorting.

Authors:  N Ramarao; T F Meyer
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

Review 2.  A meeting of good friends: when the cell biology of prokaryotes and eukaryotes meet.

Authors:  P Sebo
Journal:  Folia Microbiol (Praha)       Date:  1998       Impact factor: 2.629
  2 in total

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