| Literature DB >> 9716027 |
R L Jansen1, P S Hupperets, J W Arends, S R Joosten-Achjanie, A Volovics, H C Schouten, H F Hillen.
Abstract
The proliferative activity of a tumour is considered to be an important prognostic factor in primary breast cancer. We have investigated the prognostic value of the MIB-1 labelling index in 341 patients with primary breast cancer and compared the results with the S-phase fraction in 220 patients of the same cohort. All patients were treated in one hospital and had a median follow-up of 128 months. No correlation between MIB-1 labelling and S-phase fraction could be demonstrated. MIB-1 had prognostic value for disease-free survival in the whole group of patients (P < 0.001) and in the node-negative subgroup (P < 0.001). In multivariate analysis, MIB-1 was an independent prognostic factor (P = 0.004) besides axillary lymph node status (P = 0.001). In univariate analysis high S-phase fraction was associated with decreased overall survival (P = 0.04); however, not in multivariate analysis. Moreover, S-phase fraction had a borderline prognostic significance for post-relapse survival in multivariate analysis (P= 0.08). Thus, in conclusion, the growth fraction of a tumour as determined by the MIB-1 labelling index is an important prognostic factor in patients with primary breast cancer.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9716027 PMCID： PMC2063089 DOI： 10.1038/bjc.1998.515
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640