Literature DB >> 9712822

A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection.

D M Williams1, B G Grubbs, T Darville, K Kelly, R G Rank.   

Abstract

Interleukin-6-deficient (IL-6(-/-)) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after intranasal infection. Gamma interferon production and chlamydia-specific antibody levels were consistent with a decreased but reversible Th1-like response in IL-6(-/-) mice. IL-6 is needed for an optimal early host response to this infection.

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Year:  1998        PMID： 9712822      PMCID： PMC108560          DOI： 10.1128/IAI.66.9.4564-4567.1998

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  29 in total

1.  Chlamydia trachomatis pneumonia induces in vivo production of interleukin-1 and -6.

Authors:  D M Magee; J G Smith; C A Bleicker; C J Carter; L F Bonewald; J Schachter; D M Williams
Journal:  Infect Immun       Date:  1992-03       Impact factor: 3.441

2.  Role of CD8 T cells in primary Chlamydia infection.

Authors:  D M Magee; D M Williams; J G Smith; C A Bleicker; B G Grubbs; J Schachter; R G Rank
Journal:  Infect Immun       Date:  1995-02       Impact factor: 3.441

3.  Genetically determined differences in IL-10 and IFN-gamma responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection.

Authors:  X Yang; K T HayGlass; R C Brunham
Journal:  J Immunol       Date:  1996-06-01       Impact factor: 5.422

4.  CD8+ T lymphocyte-mediated lysis of Chlamydia-infected L cells using an endogenous antigen pathway.

Authors:  P R Beatty; R S Stephens
Journal:  J Immunol       Date:  1994-11-15       Impact factor: 5.422

5.  A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis.

Authors:  D M Williams; D M Magee; L F Bonewald; J G Smith; C A Bleicker; G I Byrne; J Schachter
Journal:  Infect Immun       Date:  1990-06       Impact factor: 3.441

6.  Role for CD8+ T cells in antichlamydial immunity defined by Chlamydia-specific T-lymphocyte clones.

Authors:  J U Igietseme; D M Magee; D M Williams; R G Rank
Journal:  Infect Immun       Date:  1994-11       Impact factor: 3.441

7.  Impaired immune and acute-phase responses in interleukin-6-deficient mice.

Authors:  M Kopf; H Baumann; G Freer; M Freudenberg; M Lamers; T Kishimoto; R Zinkernagel; H Bluethmann; G Köhler
Journal:  Nature       Date:  1994-03-24       Impact factor: 49.962

8.  Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone.

Authors:  J U Igietseme; K H Ramsey; D M Magee; D M Williams; T J Kincy; R G Rank
Journal:  Reg Immunol       Date:  1993 Nov-Dec

9.  Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans.

Authors:  L Romani; A Mencacci; E Cenci; R Spaccapelo; C Toniatti; P Puccetti; F Bistoni; V Poli
Journal:  J Exp Med       Date:  1996-04-01       Impact factor: 14.307

10.  Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis.

Authors:  M N Starnbach; M J Bevan; M F Lampe
Journal:  J Immunol       Date:  1994-12-01       Impact factor: 5.422
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  22 in total

1.  Dose-dependent induction of IL-6 by plant-derived proteases in vitro.

Authors:  B Rose; C Herder; H Löffler; G Meierhoff; N C Schloot; M Walz; S Martin
Journal:  Clin Exp Immunol       Date:  2006-01       Impact factor: 4.330

2.  Coactivating signals for the hepatic lymphocyte gamma interferon response to Francisella tularensis.

Authors:  Jason R Wickstrum; Kee-Jong Hong; Sirosh Bokhari; Natalie Reed; Nicholas McWilliams; Rebecca T Horvat; Michael J Parmely
Journal:  Infect Immun       Date:  2006-12-18       Impact factor: 3.441

Review 3.  Hypercapnia: a nonpermissive environment for the lung.

Authors:  István Vadász; Rolf D Hubmayr; Nicolás Nin; Peter H S Sporn; Jacob I Sznajder
Journal:  Am J Respir Cell Mol Biol       Date:  2012-01-12       Impact factor: 6.914

4.  Hypercapnia Inhibits Autophagy and Bacterial Killing in Human Macrophages by Increasing Expression of Bcl-2 and Bcl-xL.

Authors:  S Marina Casalino-Matsuda; Aisha Nair; Greg J Beitel; Khalilah L Gates; Peter H S Sporn
Journal:  J Immunol       Date:  2015-04-20       Impact factor: 5.422

5.  Interleukin-6 is essential for primary resistance to Francisella tularensis live vaccine strain infection.

Authors:  Sherry L Kurtz; Oded Foreman; Catharine M Bosio; Miriam R Anver; Karen L Elkins
Journal:  Infect Immun       Date:  2012-12-10       Impact factor: 3.441

6.  Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage.

Authors:  Naizhen Wang; Khalilah L Gates; Humberto Trejo; Silvio Favoreto; Robert P Schleimer; Jacob I Sznajder; Greg J Beitel; Peter H S Sporn
Journal:  FASEB J       Date:  2010-02-24       Impact factor: 5.191

7.  Differential regulation of CD4 lymphocyte recruitment between the upper and lower regions of the genital tract during Chlamydia trachomatis infection.

Authors:  K A Kelly; J C Walker; S H Jameel; H L Gray; R G Rank
Journal:  Infect Immun       Date:  2000-03       Impact factor: 3.441

8.  Toll-like receptor 2 is required for control of pulmonary infection with Francisella tularensis.

Authors:  Meenakshi Malik; Chandra Shekhar Bakshi; Bikash Sahay; Aaloki Shah; Steven A Lotz; Timothy J Sellati
Journal:  Infect Immun       Date:  2006-06       Impact factor: 3.441

9.  IL-6-mediated signaling pathways limit Chlamydia muridarum infection and exacerbate its pathogenicity in the mouse genital tract.

Authors:  Xin Sun; Qi Tian; Luying Wang; Min Xue; Guangming Zhong
Journal:  Microbes Infect       Date:  2017-08-31       Impact factor: 2.700

10.  Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection.

Authors:  Wen Cheng; Pooja Shivshankar; Zhongyu Li; Lili Chen; I-Tien Yeh; Guangming Zhong
Journal:  Infect Immun       Date:  2007-11-19       Impact factor: 3.441
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