| Literature DB >> 9712583 |
D H Munn1, M Zhou, J T Attwood, I Bondarev, S J Conway, B Marshall, C Brown, A L Mellor.
Abstract
In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian conceptus contradicts the laws of tissue transplantation. Rapid T cell-induced rejection of all allogeneic concepti occurred when pregnant mice were treated with a pharmacologic inhibitor of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme expressed by trophoblasts and macrophages. Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection.Entities:
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Year: 1998 PMID： 9712583 DOI： 10.1126/science.281.5380.1191
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728