OBJECTIVE: We administered an acute psychological stressor to multiple sclerosis (MS) patients and normal controls to determine whether differences in subjective and physiological responses to stress may underlie the susceptibility of MS patients to stress-related exacerbations. METHOD: Twenty-five MS patients (18 female, 7 male) and 25 age- and gender-matched controls participated in the study. They were asked to give a 5-minute videotaped speech defending themselves in a hypothetical scenario in which they were wrongly accused of stealing. Subjective and autonomic responses were monitored, and blood was sampled at baseline, 5, 20, and 60 minutes after the stressor to assess mitogen-stimulated production of interleukin-1beta(IL-1beta), interleukin-4 (IL-4), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma). RESULTS: MS patients and controls demonstrated similar subjective and physiological responses to the stressor that were independent of gender, mood, and disability status. The macrophage-derived cytokines IL-1beta and TNF-alpha were increased during the stressor, and remained elevated through 60 minutes. Th1 lymphocyte-derived IFN-gamma production also was increased at 5 and 60 minutes relative to baseline; however, there was no change in the Th2 lymphocyte-derived cytokine IL-4. CONCLUSIONS: These results favor the hypothesis that MS patients do not differ in stress response from normal controls; however, psychological stress may enhance cellular immune responses that would be potentially harmful to MS patients.
OBJECTIVE: We administered an acute psychological stressor to multiple sclerosis (MS) patients and normal controls to determine whether differences in subjective and physiological responses to stress may underlie the susceptibility of MSpatients to stress-related exacerbations. METHOD: Twenty-five MSpatients (18 female, 7 male) and 25 age- and gender-matched controls participated in the study. They were asked to give a 5-minute videotaped speech defending themselves in a hypothetical scenario in which they were wrongly accused of stealing. Subjective and autonomic responses were monitored, and blood was sampled at baseline, 5, 20, and 60 minutes after the stressor to assess mitogen-stimulated production of interleukin-1beta(IL-1beta), interleukin-4 (IL-4), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma). RESULTS:MSpatients and controls demonstrated similar subjective and physiological responses to the stressor that were independent of gender, mood, and disability status. The macrophage-derived cytokines IL-1beta and TNF-alpha were increased during the stressor, and remained elevated through 60 minutes. Th1 lymphocyte-derived IFN-gamma production also was increased at 5 and 60 minutes relative to baseline; however, there was no change in the Th2 lymphocyte-derived cytokine IL-4. CONCLUSIONS: These results favor the hypothesis that MSpatients do not differ in stress response from normal controls; however, psychological stress may enhance cellular immune responses that would be potentially harmful to MSpatients.
Authors: Mary W Meagher; Robin R Johnson; Erin E Young; Elisabeth G Vichaya; Shannon Lunt; Elizabeth A Hardin; Marilyn A Connor; C Jane R Welsh Journal: Brain Behav Immun Date: 2007-06-25 Impact factor: 7.217
Authors: Omer Karadag; Abdurrahman Tufan; Veli Yazisiz; Kemal Ureten; Sedat Yilmaz; Muhammet Cinar; Ali Akdogan; Hakan Erdem; Mehmet Akif Ozturk; Salih Pay; Ayhan Dinc Journal: Rheumatol Int Date: 2012-07-20 Impact factor: 2.631
Authors: Samaah Sullivan; An Young; Muhammad Hammadah; Bruno B Lima; Oleksiy Levantsevych; Yi-An Ko; Brad D Pearce; Amit J Shah; Jeong Hwan Kim; Kasra Moazzami; Emily G Driggers; Ammer Haffar; Laura Ward; Isaias Herring; Allison Hankus; Tené T Lewis; Puja K Mehta; J Douglas Bremner; Paolo Raggi; Arshed Quyyumi; Viola Vaccarino Journal: Brain Behav Immun Date: 2020-09-08 Impact factor: 7.217