| Literature DB >> 26729403 |
Stefano Marini1, Federica Vellante2, Ilaria Matarazzo2, Domenico De Berardis2,3, Nicola Serroni3, Daniela Gianfelice3, Luigi Olivieri3, Fulvia Di Renzo3, Anna Di Marco3, Michele Fornaro4, Laura Orsolini5,6, Alessandro Valchera7, Felice Iasevoli8, Monica Mazza9, Giampaolo Perna10,11,12, Giovanni Martinotti2, Massimo Di Giannantonio2.
Abstract
Major depressive disorder is a chronic and invalidating psychiatric illness and is associated with a greater risk of suicidal behaviors. In recent decades many data have supported a biological link between depressive states and inflammation. Pro-inflammatory cytokines have been found to rise, first of all TNF-α and IL-6. Suicidal behaviors have been consistently associated with increased levels of IL-6 and decreased levels of IL-2. The aim of this review is to investigate the relationship between inflammatory markers in depressed patients with or without suicidal attempts compared to healthy controls.Entities:
Keywords: inflammatory markers; major depressive disorder; suicidal attempts
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Year: 2016 PMID: 26729403 PMCID: PMC5806831 DOI: 10.1177/0394632015623793
Source DB: PubMed Journal: Int J Immunopathol Pharmacol ISSN: 0394-6320 Impact factor: 3.219