Literature DB >> 9705609

Constitutive expression of E- and P-selectin cognate ligands in human endothelial cells.

C Palma1, D Bellarosa, F Nardelli, G Mannori, S Manzini.   

Abstract

On human endothelial cells from umbilical cord (HUVEC) are present, in addition to E- and P-selectins, their cognate ligands. Differently from selectins, the ligand expression is constitutive and not modulated by interleukin-1beta. Such ligands appear to be different from the ones present in promyelocytic cells in order to promote cell adhesion to immobilized selectins. The expression of selectin-ligands on HUVEC cells suggest that selectins can participate in endothelial signalling besides their role as adhesion molecules for circulating blood cells. However, despite their role in chemotaxis, selectins do not contribute to HUVEC tube formation in Matrigel.

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Year:  1998        PMID： 9705609      PMCID： PMC1781838          DOI： 10.1080/09629359891153

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  23 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

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Journal:  Science       Date:  1990-11-23       Impact factor: 47.728

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Journal:  FASEB J       Date:  1995-07       Impact factor: 5.191

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Journal:  Nature       Date:  1995-08-10       Impact factor: 49.962

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Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808
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  1 in total

1.  Suppression of endothelial cell activity by inhibition of TNFα.

Authors:  Qiang Shu; Mohammad A Amin; Jeffrey H Ruth; Phillip L Campbell; Alisa E Koch
Journal:  Arthritis Res Ther       Date:  2012-04-25       Impact factor: 5.156
  1 in total

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