Literature DB >> 9705008

Bioassay-guided isolation of a diastereoisomer of kolavenol from Entada abyssinica active on Trypanosoma brucei rhodesiense.

F Freiburghaus1, A Steck, H Pfander, R Brun.   

Abstract

Bioassay-guided fractionation of the dichloromethane rootbark extract of Entada abyssinica (Leguminosae), a plant used by traditional healers in Uganda for the treatment of sleeping sickness, led to the isolation of a diastereoisomer of the clerodane type diterpene kolavenol. This is the first report on this compound. It showed a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.

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Year:  1998        PMID： 9705008     DOI： 10.1016/s0378-8741(98)00035-x

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  10 in total

Review 1.  Clerodane diterpenes: sources, structures, and biological activities.

Authors:  Rongtao Li; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2016-07-18       Impact factor: 13.423

2.  Activities of selected medicinal plants against multi-drug resistant Gram-negative bacteria in Cameroon.

Authors:  Marthe E S Tchana; Aimé G Fankam; Armelle T Mbaveng; Ernestine T Nkwengoua; Jackson A Seukep; Francesco K Tchouani; Barthélémy Nyassé; Victor Kuete
Journal:  Afr Health Sci       Date:  2014-03       Impact factor: 0.927

Review 3.  Biological activity of Entada phaseoloides and Entada rheedei.

Authors:  Sachiko Sugimoto; Katsuyoshi Matsunami; Hideaki Otsuka
Journal:  J Nat Med       Date:  2017-11-09       Impact factor: 2.343

4.  Functional Diversity of Diterpene Synthases in the Biofuel Crop Switchgrass.

Authors:  Kyle A Pelot; Ruibing Chen; David M Hagelthorn; Cari A Young; J Bennett Addison; Andrew Muchlinski; Dorothea Tholl; Philipp Zerbe
Journal:  Plant Physiol       Date:  2018-07-15       Impact factor: 8.340

5.  Antimicrobial and antioxidant properties of methanol extract, fractions and compounds from the stem bark of Entada abyssinica Stend ex A. Satabie.

Authors:  Gerald N Teke; Paul K Lunga; Hippolyte K Wabo; Jules-Roger Kuiate; Gerard Vilarem; Geraldine Giacinti; Haruhisa Kikuchi; Yoshiteru Oshima
Journal:  BMC Complement Altern Med       Date:  2011-07-19       Impact factor: 3.659

Review 6.  Ethnopharmacological Survey of Plants Used in the Traditional Treatment of Gastrointestinal Pain, Inflammation and Diarrhea in Africa: Future Perspectives for Integration into Modern Medicine.

Authors:  Timo D Stark; Dorah J Mtui; Onesmo B Balemba
Journal:  Animals (Basel)       Date:  2013-03-04       Impact factor: 2.752

7.  Cytotoxicity, antimicrobial and antioxidant activity of eight compounds isolated from Entada abyssinica (Fabaceae).

Authors:  Jean P Dzoyem; Raduis Melong; Armelle T Tsamo; Alembert T Tchinda; Deccaux G W F Kapche; Bonaventure T Ngadjui; Lyndy J McGaw; Jacobus N Eloff
Journal:  BMC Res Notes       Date:  2017-03-06

Review 8.  The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases.

Authors:  Peter Mubanga Cheuka; Godfrey Mayoka; Peggoty Mutai; Kelly Chibale
Journal:  Molecules       Date:  2016-12-31       Impact factor: 4.411

9.  In vivo evaluation of the toxic activity and genotoxicity of the Hymenaea courbaril L.'s resin in Drosophila melanogaster.

Authors:  Jorge Anaya-Gil; Patricia Ramos-Morales; Adriana Muñoz-Hernandez; Adriana Bermúdez; Harold Gomez-Estrada
Journal:  Saudi J Biol Sci       Date:  2021-09-13       Impact factor: 4.219

10.  Traditional medicinal plant knowledge and use by local healers in Sekoru District, Jimma Zone, Southwestern Ethiopia.

Authors:  Haile Yineger; Delenasaw Yewhalaw
Journal:  J Ethnobiol Ethnomed       Date:  2007-06-04       Impact factor: 2.733
  10 in total

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