Literature DB >> 9704089

Aptamers as potential nucleic acid pharmaceuticals.

A D Ellington1, R Conrad.   

Abstract

In vitro selection is a technique for the isolation of nucleic acid ligands that can bind to proteins with high affinity and specificity, and has potential applications in the development of new pharmaceuticals. This review summarizes the protein targets that have successfully elicited nucleic acid binding species (also known as "aptamers") and explores examples of how they might be developed for clinical use. In particular, the use of aptamers for the alleviation of blood clotting and the treatment of AIDS are considered.

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Year:  1995        PMID： 9704089     DOI： 10.1016/s1387-2656(08)70052-8

Source DB:  PubMed          Journal:  Biotechnol Annu Rev        ISSN： 1387-2656


  7 in total

1.  In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1.

Authors:  F Ducongé; J J Toulmé
Journal:  RNA       Date:  1999-12       Impact factor: 4.942

2.  Anti-Rex aptamers as mimics of the Rex-binding element.

Authors:  S Baskerville; M Zapp; A D Ellington
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

3.  Aptamer selection express: a novel method for rapid single-step selection and sensing of aptamers.

Authors:  Maomian Fan; Shelly Roper McBurnett; Carrie J Andrews; Amity M Allman; John G Bruno; Johnathan L Kiel
Journal:  J Biomol Tech       Date:  2008-12

Review 4.  In vitro selection methodologies to probe RNA function and structure.

Authors:  R C Conrad; S Baskerville; A D Ellington
Journal:  Mol Divers       Date:  1995-09       Impact factor: 2.943

5.  In vitro Selection of DNA Aptamers to Glioblastoma Multiforme.

Authors:  Abdullah Tahir Bayrac; Kwame Sefah; Parag Parekh; Ceren Bayrac; Basri Gulbakan; Huseyin Avni Oktem; Weihong Tan
Journal:  ACS Chem Neurosci       Date:  2011-01-31       Impact factor: 4.418

6.  Metabolism, pharmacokinetics, tissue distribution, and stability studies of the prodrug analog of an anti-hepatitis B virus dinucleoside phosphorothioate.

Authors:  John E Coughlin; Rajendra K Pandey; Seetharamaiyer Padmanabhan; Kathleen G O'Loughlin; Judith Marquis; Carol E Green; Jon C Mirsalis; Radhakrishnan P Iyer
Journal:  Drug Metab Dispos       Date:  2012-02-10       Impact factor: 3.922

7.  Developing aptamer probes for acute myelogenous leukemia detection and surface protein biomarker discovery.

Authors:  Mingli Yang; Guohua Jiang; Wenjing Li; Kai Qiu; Min Zhang; Christopher M Carter; Samer Z Al-Quran; Ying Li
Journal:  J Hematol Oncol       Date:  2014-01-09       Impact factor: 17.388
  7 in total

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