| Literature DB >> 9701252 |
S Palfi1, F Condé, D Riche, E Brouillet, C Dautry, V Mittoux, A Chibois, M Peschanski, P Hantraye.
Abstract
Substitutive therapy using fetal striatal grafts in animal models of Huntington disease (HD) have already demonstrated obvious beneficial effects on motor indices. Using a new phenotypic model of HD recently designed in primates, we demonstrate here complete and persistent recovery in a frontal-type cognitive task two to five months after intrastriatal allografting. The striatal allografts also reduce the occurrence of dystonia, a major abnormal movement associated with HD. These results show the capacity of fetal neurons to provide a renewed substrate for both cognitive and motor systems in the lesioned adult brain. They also support the use of neural transplantation as a potential therapy for HD.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9701252 DOI： 10.1038/nm0898-963
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440