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Literature DB >> 15865888

Stem cell therapy for central nervous system demyelinating disease.

Louis N Manganas¹, Mirjana Maletic-Savatic.

Abstract

Recent advances in cell-based therapies for demyelinating central nervous system diseases have demonstrated the ability to restore damaged neuronal architecture and function. Demyelinated axons in patients with multiple sclerosis can spontaneously remyelinate over time; however, the rate and extent at which remyelination occurs is inadequate for complete recovery. Previous attempts aimed at regenerating myelin-forming cells have been successful but limited by the multifocal nature of the lesions and the inability to produce large numbers of myelin-producing cells in culture. Stem cell-based therapy can overcome these limitations to some extent and may prove useful in the future treatment of demyelinating diseases.

Entities: Disease Species

Mesh：

Year: 2005 PMID： 15865888 PMCID： PMC4031751 DOI： 10.1007/s11910-005-0050-z

Source DB: PubMed Journal: Curr Neurol Neurosci Rep ISSN： 1528-4042 Impact factor: 5.081

73 in total

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Authors: R M Ransohoff
Journal: J Infect Dis Date: 2002-12-01 Impact factor: 5.226

2. Remyelination of the spinal cord following intravenous delivery of bone marrow cells.

Authors: Yukinori Akiyama; Christine Radtke; Osamu Honmou; Jeffery D Kocsis
Journal: Glia Date: 2002-09 Impact factor: 7.452

3. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes.

Authors: Manuel Alvarez-Dolado; Ricardo Pardal; Jose M Garcia-Verdugo; John R Fike; Hyun O Lee; Klaus Pfeffer; Carlos Lois; Sean J Morrison; Arturo Alvarez-Buylla
Journal: Nature Date: 2003-10-12 Impact factor: 49.962

Review 4. Reactive astrocytes: cellular and molecular cues to biological function.

Authors: J L Ridet; S K Malhotra; A Privat; F H Gage
Journal: Trends Neurosci Date: 1997-12 Impact factor: 13.837

5. Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis.

Authors: P D Murray; D B McGavern; S Sathornsumetee; M Rodriguez
Journal: Brain Date: 2001-07 Impact factor: 13.501

6. Pattern of remyelination in the CNS.

Authors: W F Blakemore
Journal: Nature Date: 1974-06-07 Impact factor: 49.962

7. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases.

Authors: C Lucchinetti; W Brück; J Parisi; B Scheithauer; M Rodriguez; H Lassmann
Journal: Brain Date: 1999-12 Impact factor: 13.501

8. In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination.

Authors: J M Redwine; R C Armstrong
Journal: J Neurobiol Date: 1998-11-15

9. Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance.

Authors: Frederik Barkhof; Wolfgang Bruck; Corline J A De Groot; Elisabeth Bergers; Sandra Hulshof; Jeroen Geurts; Chris H Polman; Paul van der Valk
Journal: Arch Neurol Date: 2003-08

10. Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system.

Authors: P Villoslada; S L Hauser; I Bartke; J Unger; N Heald; D Rosenberg; S W Cheung; W C Mobley; S Fisher; C P Genain
Journal: J Exp Med Date: 2000-05-15 Impact factor: 14.307

6 in total

Stem cell therapy for central nervous system demyelinating disease.

Review 1. The chemokine system in neuroinflammation: an update.

2. Remyelination of the spinal cord following intravenous delivery of bone marrow cells.

3. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes.

Review 4. Reactive astrocytes: cellular and molecular cues to biological function.

5. Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis.

6. Pattern of remyelination in the CNS.

7. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases.

8. In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination.

9. Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance.

10. Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system.

1. Transgenic mouse models for studying adult neurogenesis.

2. Mouse Models for Studying Hippocampal Adult Neural Stem Cell Biology.

3. Oligoprogenitor cells derived from spermatogonia stem cells improve remyelination in demyelination model.

4. A question of fate.

5. A 3D disease and regeneration model of peripheral nervous system-on-a-chip.

6. BASP1 labels neural stem cells in the neurogenic niches of mammalian brain.