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Literature DB >> 9699678

Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence.

Abstract

The putative Brca2-MmRad51 interaction is analyzed in mouse cells deleted for the COOH terminus of Brca2 (amino acids 3140-3328), which contains a region that associates with MmRad51 by yeast two-hybrid. These cells are hypersensitive to gamma-radiation (suggesting defective recombinational repair) but not UV light (suggesting intact nucleotide excision repair) and maintain the G1-S and G2-M checkpoints after exposure to gamma-irradiation. Cells deleted for the COOH terminus of Brca2 progress through the cell cycle at a similar rate as wild-type cells but undergo senescence more rapidly. These data support the hypothesis that deletion of Brca2 stimulates cancer by defective MmRad51-mediated DNA repair and not by defective cell cycle regulation.

Entities: Disease Gene Species

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Year: 1998 PMID： 9699678

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

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Cited

36 in total

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7. Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer.

Authors: Yanhong Liu; Christine M Lusk; Michael H Cho; Edwin K Silverman; Dandi Qiao; Ruyang Zhang; Michael E Scheurer; Farrah Kheradmand; David A Wheeler; Spiridon Tsavachidis; Georgina Armstrong; Dakai Zhu; Ignacio I Wistuba; Chi-Wan B Chow; Carmen Behrens; Claudio W Pikielny; Christine Neslund-Dudas; Susan M Pinney; Marshall Anderson; Elena Kupert; Joan Bailey-Wilson; Colette Gaba; Diptasri Mandal; Ming You; Mariza de Andrade; Ping Yang; John K Field; Triantafillos Liloglou; Michael Davies; Jolanta Lissowska; Beata Swiatkowska; David Zaridze; Anush Mukeriya; Vladimir Janout; Ivana Holcatova; Dana Mates; Sasa Milosavljevic; Ghislaine Scelo; Paul Brennan; James McKay; Geoffrey Liu; Rayjean J Hung; David C Christiani; Ann G Schwartz; Christopher I Amos; Margaret R Spitz
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