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Literature DB >> 21731065

Unraveling the mechanism of BRCA2 in homologous recombination.

Abstract

BRCA2 is the product of a breast cancer susceptibility gene in humans and the founding member of an emerging family of proteins present throughout the eukaryotic domain that serve in homologous recombination. The function of BRCA2 in recombination is to control RAD51, a protein that catalyzes homologous pairing and DNA strand exchange. By physically interacting with both RAD51 and single-stranded DNA, BRCA2 mediates delivery of RAD51 preferentially to sites of single-stranded DNA (ssDNA) exposed as a result of DNA damage or replication problems. Through its action, BRCA2 helps restore and maintain integrity of the genome. This review highlights recent studies on BRCA2 and its orthologs that have begun to illuminate the molecular mechanisms by which these proteins control homologous recombination.

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Year: 2011 PMID： 21731065 PMCID： PMC3647347 DOI： 10.1038/nsmb.2096

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

87 in total

Review 1. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis.

Authors: Mary Ellen Moynahan; Maria Jasin
Journal: Nat Rev Mol Cell Biol Date: 2010-03 Impact factor: 94.444

2. Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination.

Authors: Rémi Buisson; Anne-Marie Dion-Côté; Yan Coulombe; Hélène Launay; Hong Cai; Alicja Z Stasiak; Andrzej Stasiak; Bing Xia; Jean-Yves Masson
Journal: Nat Struct Mol Biol Date: 2010-09-26 Impact factor: 15.369

3. Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification.

Authors: A Tutt; A Gabriel; D Bertwistle; F Connor; H Paterson; J Peacock; G Ross; A Ashworth
Journal: Curr Biol Date: 1999-10-07 Impact factor: 10.834

4. Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.

Authors: C F Chen; P L Chen; Q Zhong; Z D Sharp; W H Lee
Journal: J Biol Chem Date: 1999-11-12 Impact factor: 5.157

5. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

Authors: Eloïse Dray; Julia Etchin; Claudia Wiese; Dorina Saro; Gareth J Williams; Michal Hammel; Xiong Yu; Vitold E Galkin; Dongqing Liu; Miaw-Sheue Tsai; Shirley M-H Sy; David Schild; Edward Egelman; Junjie Chen; Patrick Sung
Journal: Nat Struct Mol Biol Date: 2010-09-26 Impact factor: 15.369

6. Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.

Authors: Jie Liu; Tammy Doty; Bryan Gibson; Wolf-Dietrich Heyer
Journal: Nat Struct Mol Biol Date: 2010-08-22 Impact factor: 15.369

7. Brh2 promotes a template-switching reaction enabling recombinational bypass of lesions during DNA synthesis.

Authors: Nayef Mazloum; William K Holloman
Journal: Mol Cell Date: 2009-11-25 Impact factor: 17.970

8. The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange.

Authors: Mahmud K K Shivji; Shreyas R Mukund; Eeson Rajendra; Shaoxia Chen; Judith M Short; Jane Savill; David Klenerman; Ashok R Venkitaraman
Journal: Proc Natl Acad Sci U S A Date: 2009-07-23 Impact factor: 11.205

9. The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

Authors: Tina Thorslund; Michael J McIlwraith; Sarah A Compton; Sergey Lekomtsev; Mark Petronczki; Jack D Griffith; Stephen C West
Journal: Nat Struct Mol Biol Date: 2010-08-22 Impact factor: 15.369

10. Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase.

Authors: Eeson Rajendra; Ashok R Venkitaraman
Journal: Nucleic Acids Res Date: 2009-10-29 Impact factor: 16.971

82 in total

Review 1. Poly (ADP-ribose) polymerase inhibitors: on the horizon of tailored and personalized therapies for epithelial ovarian cancer.

Authors: Elena S Ratner; Alan C Sartorelli; Z Ping Lin
Journal: Curr Opin Oncol Date: 2012-09 Impact factor: 3.645

9. Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors.

Authors: Poorval M Joshi; Shari L Sutor; Catherine J Huntoon; Larry M Karnitz
Journal: J Biol Chem Date: 2014-02-19 Impact factor: 5.157

Review 10. Telomere recombination pathways: tales of several unhappy marriages.

Authors: Neal F Lue; Eun Young Yu
Journal: Curr Genet Date: 2016-09-25 Impact factor: 3.886

Unraveling the mechanism of BRCA2 in homologous recombination.

Review 1. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis.

2. Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination.

3. Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification.

4. Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.

5. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

6. Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.

7. Brh2 promotes a template-switching reaction enabling recombinational bypass of lesions during DNA synthesis.

8. The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange.

9. The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

10. Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase.

Review 1. Poly (ADP-ribose) polymerase inhibitors: on the horizon of tailored and personalized therapies for epithelial ovarian cancer.

2. Dss1 Regulates Association of Brh2 with Rad51.

Review 3. Targeting the homologous recombination pathway by small molecule modulators.

4. LAMMER kinase contributes to genome stability in Ustilago maydis.

Review 5. Mechanisms of DNA damage, repair, and mutagenesis.

6. Antimüllerian hormone levels are lower in BRCA2 mutation carriers.

Review 7. Functional assays for analysis of variants of uncertain significance in BRCA2.

8. Dss1 release activates DNA binding potential in Brh2.

9. Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors.

Review 10. Telomere recombination pathways: tales of several unhappy marriages.