Literature DB >> 9697409

Protein-PCNA interactions: a DNA-scanning mechanism?

Z Kelman1, J Hurwitz.   

Abstract

Proliferating-cell nuclear antigen (PCNA) plays an essential role in nucleic-acid metabolism in all eukaryotes. The PCNA protein interacts with a large number of proteins. These proteins can be divided into two groups: the first contains proteins that have a known enzymatic activity; the second contains regulatory proteins that are involved in cell-cycle progression, checkpoint control and cellular differentiation. Interestingly, all of the enzymes known to interact with PCNA either recognize specific structures on DNA or have limited DNA-sequence specificity. Proteins that have low sequence specificities could utilize PCNA as an adapter in order to interact with their DNA substrates.

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Year:  1998        PMID： 9697409     DOI： 10.1016/s0968-0004(98)01223-7

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  46 in total

Review 1.  Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I.

Authors:  F J López de Saro; M O'Donnell
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

2.  Structure-function analysis of fission yeast Hus1-Rad1-Rad9 checkpoint complex.

Authors:  R Kaur; C F Kostrub; T Enoch
Journal:  Mol Biol Cell       Date:  2001-12       Impact factor: 4.138

3.  Intermolecular ion pairs maintain the toroidal structure of Pyrococcus furiosus PCNA.

Authors:  Shigeki Matsumiya; Sonoko Ishino; Yoshizumi Ishino; Kosuke Morikawa
Journal:  Protein Sci       Date:  2003-04       Impact factor: 6.725

4.  C4 protein of Beet severe curly top virus is a pathomorphogenetic factor in Arabidopsis.

Authors:  Jungan Park; Hyun-Sik Hwang; Kenneth J Buckley; Jong-Bum Park; Chung-Kyun Auh; Dong-Giun Kim; Sukchan Lee; Keith R Davis
Journal:  Plant Cell Rep       Date:  2010-10-20       Impact factor: 4.570

5.  Characterization of dRFX2, a novel RFX family protein in Drosophila.

Authors:  Kyoko Otsuki; Yuko Hayashi; Masaki Kato; Hideki Yoshida; Masamitsu Yamaguchi
Journal:  Nucleic Acids Res       Date:  2004-10-19       Impact factor: 16.971

6.  Stoichiometric complex formation by proliferating cell nuclear antigen (PCNA) and its interacting protein: purification and crystallization of the DNA polymerase and PCNA monomer mutant complex from Pyrococcus furiosus.

Authors:  Hirokazu Nishida; Shigeki Matsumiya; Daisuke Tsuchiya; Yoshizumi Ishino; Kosuke Morikawa
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-02-24

7.  Interactions and subcellular distribution of DNA replication initiation proteins in eukaryotic cells.

Authors:  Normen Brand; Thomas Faul; Friedrich Grummt
Journal:  Mol Genet Genomics       Date:  2007-08-07       Impact factor: 3.291

8.  Functional interactions of a homolog of proliferating cell nuclear antigen with DNA polymerases in Archaea.

Authors:  I K Cann; S Ishino; I Hayashi; K Komori; H Toh; K Morikawa; Y Ishino
Journal:  J Bacteriol       Date:  1999-11       Impact factor: 3.490

9.  Streamlined, automated protocols for the production of milligram quantities of untagged recombinant human cyclophilin-A (hCypA) and untagged human proliferating cell nuclear antigen (hPCNA) using AKTAxpress.

Authors:  Cornelia Ludwig; Martin A Wear; Malcolm D Walkinshaw
Journal:  Protein Expr Purif       Date:  2009-12-06       Impact factor: 1.650

10.  Construction of a circular single-stranded DNA template containing a defined lesion.

Authors:  Kiyonobu Karata; Antonio E Vidal; Roger Woodgate
Journal:  DNA Repair (Amst)       Date:  2009-04-21
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