Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A new NEDD8-ligating system for cullin-4A.

Literature DB >> 9694792

A new NEDD8-ligating system for cullin-4A.

F Osaka¹, H Kawasaki, N Aida, M Saeki, T Chiba, S Kawashima, K Tanaka, S Kato.

Abstract

NEDD8 is a ubiquitin (Ub)-like protein. Here we report a novel ubiquitinylation-related pathway for modification by NEDD8. NEDD8 was activated by an E1 (Ub-activating enzyme)-like complex, consisting of APP-BP1 and hUba3 with high respective homologies to the amino- and carboxy-terminal regions of E1 and then linked to hUbc12 (a human homolog of yeast Ub-conjugating enzyme Ubc12p). The major target protein modified by NEDD8 was found to be Hs-cullin-4A (Cul-4A), a member of the family of human cullin/Cdc53 proteins functioning as an essential component of a multifunctional Ub-protein ligase E3 complex that has a critical role in Ub-mediated proteolysis.

Entities: Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9694792 PMCID： PMC317039 DOI： 10.1101/gad.12.15.2263

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

31 in total

1. Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p.

Authors: E S Johnson; G Blobel
Journal: J Biol Chem Date: 1997-10-24 Impact factor: 5.157

2. Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle.

Authors: F N Li; M Johnston
Journal: EMBO J Date: 1997-09-15 Impact factor: 11.598

3. SUMO-1: Ubiquitin gains weight.

Authors: P R Johnson; M Hochstrasser
Journal: Trends Cell Biol Date: 1997-10 Impact factor: 20.808

Review 4. Structure and functions of the 20S and 26S proteasomes.

Authors: O Coux; K Tanaka; A L Goldberg
Journal: Annu Rev Biochem Date: 1996 Impact factor: 23.643

5. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein.

Authors: T Kamitani; K Kito; H P Nguyen; E T Yeh
Journal: J Biol Chem Date: 1997-11-07 Impact factor: 5.157

Review 6. Cell cycle: cull and destroy.

Authors: P K Jackson
Journal: Curr Biol Date: 1996-10-01 Impact factor: 10.834

7. Cloning of a cDNA which encodes a novel ubiquitin-like protein.

Authors: S Kumar; Y Yoshida; M Noda
Journal: Biochem Biophys Res Commun Date: 1993-08-31 Impact factor: 3.575

8. The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme.

Authors: S E Schwarz; K Matuschewski; D Liakopoulos; M Scheffner; S Jentsch
Journal: Proc Natl Acad Sci U S A Date: 1998-01-20 Impact factor: 11.205

9. Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex.

Authors: D Lammer; N Mathias; J M Laplaza; W Jiang; Y Liu; J Callis; M Goebl; M Estelle
Journal: Genes Dev Date: 1998-04-01 Impact factor: 11.361

10. An essential yeast gene encoding a homolog of ubiquitin-activating enzyme.

Authors: R J Dohmen; R Stappen; J P McGrath; H Forrová; J Kolarov; A Goffeau; A Varshavsky
Journal: J Biol Chem Date: 1995-07-28 Impact factor: 5.157

100 in total

Review 1. Two distinct ubiquitin-proteolysis pathways in the fission yeast cell cycle.

Authors: T Toda; I Ochotorena; K Kominami
Journal: Philos Trans R Soc Lond B Biol Sci Date: 1999-09-29 Impact factor: 6.237

2. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle.

Authors: E Freed; K R Lacey; P Huie; S A Lyapina; R J Deshaies; T Stearns; P K Jackson
Journal: Genes Dev Date: 1999-09-01 Impact factor: 11.361

3. A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2.

Authors: Y C Liu; J Pan; C Zhang; W Fan; M Collinge; J R Bender; S M Weissman
Journal: Proc Natl Acad Sci U S A Date: 1999-04-13 Impact factor: 11.205

4. The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1.

Authors: M Furukawa; Y Zhang; J McCarville; T Ohta; Y Xiong
Journal: Mol Cell Biol Date: 2000-11 Impact factor: 4.272

5. Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast.

Authors: F Osaka; M Saeki; S Katayama; N Aida; A Toh-E; K Kominami; T Toda; T Suzuki; T Chiba; K Tanaka; S Kato
Journal: EMBO J Date: 2000-07-03 Impact factor: 11.598

6. Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex.

Authors: E Querido; P Blanchette; Q Yan; T Kamura; M Morrison; D Boivin; W G Kaelin; R C Conaway; J W Conaway; P E Branton
Journal: Genes Dev Date: 2001-12-01 Impact factor: 11.361

7. NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

Authors: T Kawakami; T Chiba; T Suzuki; K Iwai; K Yamanaka; N Minato; H Suzuki; N Shimbara; Y Hidaka; F Osaka; M Omata; K Tanaka
Journal: EMBO J Date: 2001-08-01 Impact factor: 11.598

8. Molecular characterization of mouse gastric epithelial progenitor cells.

Authors: Jason C Mills; Niklas Andersson; Chieu V Hong; Thaddeus S Stappenbeck; Jeffrey I Gordon
Journal: Proc Natl Acad Sci U S A Date: 2002-10-30 Impact factor: 11.205

9. Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.

Authors: Chan-Yen Ou; Yi-Fan Lin; Ying-Jiun Chen; Cheng-Ting Chien
Journal: Genes Dev Date: 2002-09-15 Impact factor: 11.361

10. Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo.

Authors: Jose M Laplaza; Magnolia Bostick; Derek T Scholes; M Joan Curcio; Judy Callis
Journal: Biochem J Date: 2004-01-15 Impact factor: 3.857