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Literature DB >> 8395831

Cloning of a cDNA which encodes a novel ubiquitin-like protein.

Abstract

The cloning of a mouse cDNA, Nedd-8, which encodes a small novel protein of 81 amino acid residues with a relative molecular mass of 9 kDa, is described. The putative Nedd-8 product is approximately 60% identical to ubiquitin protein. The 0.6 kb mRNA for Nedd-8 gene can be detected in various mouse tissues and cell lines derived from various sources. Nedd-8 probe hybridizes to genomic DNA from various vertebrate species as well as yeast, indicating high degree of interspecies conservation. These data suggest that like ubiquitin, the product of this gene may play some essential role in eukaryotic cellular metabolism.

Entities: Gene Species

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Year: 1993 PMID： 8395831 DOI： 10.1006/bbrc.1993.2056

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

44 in total

1. The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1.

Authors: M Furukawa; Y Zhang; J McCarville; T Ohta; Y Xiong
Journal: Mol Cell Biol Date: 2000-11 Impact factor: 4.272

2. Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast.

Authors: F Osaka; M Saeki; S Katayama; N Aida; A Toh-E; K Kominami; T Toda; T Suzuki; T Chiba; K Tanaka; S Kato
Journal: EMBO J Date: 2000-07-03 Impact factor: 11.598

3. Up-regulation of interferon-stimulated gene15 and its conjugates by tumor necrosis factor-α via type I interferon-dependent and -independent pathways.

Authors: Kongthawat Chairatvit; Ariyaphong Wongnoppavich; Sirinthip Choonate
Journal: Mol Cell Biochem Date: 2012-06-23 Impact factor: 3.396

Review 4. Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series.

Authors: Gwénaël Rabut; Matthias Peter
Journal: EMBO Rep Date: 2008-09-19 Impact factor: 8.807

5. Inhibition of neddylation causes meiotic arrest in mouse oocyte.

Authors: Mo Yang; Yimei Jin; Siying Fan; Xiaoling Liang; Jialin Jia; Zhongzhou Tan; Tao Huang; Yuan Li; Teng Ma; Mo Li
Journal: Cell Cycle Date: 2019-05-21 Impact factor: 4.534

6. NEDD8 ultimate buster-1 long (NUB1L) protein promotes transfer of NEDD8 to proteasome for degradation through the P97UFD1/NPL4 complex.

Authors: Shuai Liu; Hui Yang; Jian Zhao; Yu-Hang Zhang; Ai-Xin Song; Hong-Yu Hu
Journal: J Biol Chem Date: 2013-09-09 Impact factor: 5.157

Cloning of a cDNA which encodes a novel ubiquitin-like protein.

1. The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1.

2. Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast.

3. Up-regulation of interferon-stimulated gene15 and its conjugates by tumor necrosis factor-α via type I interferon-dependent and -independent pathways.

Review 4. Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series.

5. Inhibition of neddylation causes meiotic arrest in mouse oocyte.

6. NEDD8 ultimate buster-1 long (NUB1L) protein promotes transfer of NEDD8 to proteasome for degradation through the P97UFD1/NPL4 complex.

Review 7. Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy.

8. Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana.

Review 9. Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications.

10. Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo.