S Fukudo1, T Nomura, M Hongo. 1. Department of Psychosomatic Medicine, Tohoku University School of Medicine, Sendai, Japan.
Abstract
BACKGROUND: Corticotropin-releasing hormone (CRH) plays a key role in modulating intestinal motility in stressed animals. AIMS: To evaluate the effect of CRH on intestinal motility in humans and to determine whether patients with irritable bowel syndrome (IBS) have an exaggerated response to CRH. SUBJECTS: Ten IBS patients diagnosed by Rome criteria and 10 healthy controls. METHODS: CRH (2 micrograms/kg) was intravenously administered during duodenal and colonic manometry and plasma adrenocorticotropic hormone (ACTH) was measured by radioimmunoassay. RESULTS: CRH induced motility of the descending colon in both groups (p < 0.001) and induced greater motility indexes in IBS patients than in controls (p < 0.05). CRH produced duodenal phase III motor activity in 80% of the subjects and duodenal dysmotility in 40% of IBS patients. Abdominal symptoms evoked by CRH in IBS patients lasted significantly longer than those in controls (p < 0.05). CRH induced significant increases in plasma ACTH levels in both groups (p < 0.001) and produced significantly higher plasma ACTH levels in IBS patients than in controls (p < 0.001). CONCLUSION: Human intestinal motility is probably modulated by exogenous CRH. The brain-gut in IBS patients may have an exaggerated response to CRH.
BACKGROUND:Corticotropin-releasing hormone (CRH) plays a key role in modulating intestinal motility in stressed animals. AIMS: To evaluate the effect of CRH on intestinal motility in humans and to determine whether patients with irritable bowel syndrome (IBS) have an exaggerated response to CRH. SUBJECTS: Ten IBSpatients diagnosed by Rome criteria and 10 healthy controls. METHODS:CRH (2 micrograms/kg) was intravenously administered during duodenal and colonic manometry and plasma adrenocorticotropic hormone (ACTH) was measured by radioimmunoassay. RESULTS:CRH induced motility of the descending colon in both groups (p < 0.001) and induced greater motility indexes in IBSpatients than in controls (p < 0.05). CRH produced duodenal phase III motor activity in 80% of the subjects and duodenal dysmotility in 40% of IBSpatients. Abdominal symptoms evoked by CRH in IBSpatients lasted significantly longer than those in controls (p < 0.05). CRH induced significant increases in plasma ACTH levels in both groups (p < 0.001) and produced significantly higher plasma ACTH levels in IBSpatients than in controls (p < 0.001). CONCLUSION:Human intestinal motility is probably modulated by exogenous CRH. The brain-gut in IBSpatients may have an exaggerated response to CRH.
Authors: A R Hermus; G F Pieters; J J Willemsen; H A Ross; A G Smals; T J Benraad; P W Kloppenborg Journal: Eur J Clin Pharmacol Date: 1987 Impact factor: 2.953
Authors: T Suda; N Tomori; F Yajima; T Sumitomo; Y Nakagami; T Ushiyama; H Demura; K Shizume Journal: J Clin Invest Date: 1985-11 Impact factor: 14.808
Authors: K E Habib; K P Weld; K C Rice; J Pushkas; M Champoux; S Listwak; E L Webster; A J Atkinson; J Schulkin; C Contoreggi; G P Chrousos; S M McCann; S J Suomi; J D Higley; P W Gold Journal: Proc Natl Acad Sci U S A Date: 2000-05-23 Impact factor: 11.205
Authors: J Jones; J Boorman; P Cann; A Forbes; J Gomborone; K Heaton; P Hungin; D Kumar; G Libby; R Spiller; N Read; D Silk; P Whorwell Journal: Gut Date: 2000-11 Impact factor: 23.059