AIM: Our group has previously shown that the administration of pasta enriched along with the prebiotic inulin induces a significant reduction in triglyceride and glucose levels with a significant delay in gastric emptying (GE) rates. This protective effect may occur by affecting the release of a number of gut peptides involved in the control of gastrointestinal motility. The aim of the present study was to evaluate the effects of inulin-enriched pasta on the circulating levels of neurotensin (NT), somatostatin (SS), and corticotropin-releasing factor (CRF) in relation to the GE time in young healthy subjects. METHODS:Twenty healthy young male volunteers completed a randomized double-blind crossover study consisting of a 2-week run-in period and two 5-week study periods (11% inulin-enriched/control pasta), with an 8-week wash-out period in between. Gut peptide concentrations were evaluated by radioimmunoassay. GE time was evaluated by ultrasonography. RESULTS: The prebiotic treatment significantly increased the area under the curve (AUC) values of both NT and SS (p < 0.05 Dunn's post-test). With regard to gastric motility, along with a significant delay in both the final time and T (1/2) gastric emptying time, a positive correlation was found between T (1/2) and SS AUC values (r = 0.57, p = 0.009) in the inulin-enriched pasta group. CONCLUSION: These results support the hypothesis that inulin plays an active role in mechanisms affecting the release of these gut peptides, which may modulate the gastric emptying of digesta.
RCT Entities:
AIM: Our group has previously shown that the administration of pasta enriched along with the prebiotic inulin induces a significant reduction in triglyceride and glucose levels with a significant delay in gastric emptying (GE) rates. This protective effect may occur by affecting the release of a number of gut peptides involved in the control of gastrointestinal motility. The aim of the present study was to evaluate the effects of inulin-enriched pasta on the circulating levels of neurotensin (NT), somatostatin (SS), and corticotropin-releasing factor (CRF) in relation to the GE time in young healthy subjects. METHODS: Twenty healthy young male volunteers completed a randomized double-blind crossover study consisting of a 2-week run-in period and two 5-week study periods (11% inulin-enriched/control pasta), with an 8-week wash-out period in between. Gut peptide concentrations were evaluated by radioimmunoassay. GE time was evaluated by ultrasonography. RESULTS: The prebiotic treatment significantly increased the area under the curve (AUC) values of both NT and SS (p < 0.05 Dunn's post-test). With regard to gastric motility, along with a significant delay in both the final time and T (1/2) gastric emptying time, a positive correlation was found between T (1/2) and SS AUC values (r = 0.57, p = 0.009) in the inulin-enriched pasta group. CONCLUSION: These results support the hypothesis that inulin plays an active role in mechanisms affecting the release of these gut peptides, which may modulate the gastric emptying of digesta.
Authors: F Russo; G Riezzo; M Chiloiro; G De Michele; G Chimienti; E Marconi; B D'Attoma; M Linsalata; C Clemente Journal: Curr Pharm Des Date: 2010 Impact factor: 3.116
Authors: Esther Zorio; Cristina Falco; Miguel A Arnau; Francisco España; Ana Osa; Luis A Ramon; Remedios Castello; Luis Almenar; Miguel A Palencia; Amparo Estelles Journal: Haematologica Date: 2006-04 Impact factor: 9.941
Authors: Enid E Martinez; David Zurakowski; Luis Pereira; Rachel Freire; John B Emans; Samuel Nurko; Christopher P Duggan; Alessio Fasano; Nilesh M Mehta Journal: JPEN J Parenter Enteral Nutr Date: 2020-06-03 Impact factor: 4.016