Literature DB >> 9689486

Microinjection of morphine into the rostral ventromedial medulla produces greater antinociception in male compared to female rats.

J S Boyer1, M M Morgan, R M Craft.   

Abstract

The antinociceptive and locomotor effects of microinjecting morphine into the rostral ventromedial medulla (RVM) of male and female rats was assessed. Male rats showed greater antinociception than female rats at all doses and times following morphine administration. Male, but not female rats, also showed a dose dependent decrease in locomotion. These data demonstrate that sex differences in antinociception are mediated at least in part by the RVM.

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Year:  1998        PMID： 9689486     DOI： 10.1016/s0006-8993(98)00353-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  24 in total

1.  PAG mu opioid receptor activation underlies sex differences in morphine antinociception.

Authors:  Scott A Bernal; Michael M Morgan; Rebecca M Craft
Journal:  Behav Brain Res       Date:  2006-11-21       Impact factor: 3.332

2.  Sex differences in the anatomical and functional organization of the periaqueductal gray-rostral ventromedial medullary pathway in the rat: a potential circuit mediating the sexually dimorphic actions of morphine.

Authors:  Dayna R Loyd; Anne Z Murphy
Journal:  J Comp Neurol       Date:  2006-06-10       Impact factor: 3.215

3.  Persistent pain model reveals sex difference in morphine potency.

Authors:  Xiaoya Wang; Richard J Traub; Anne Z Murphy
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2006-02-23       Impact factor: 3.619

4.  Effects of morphine on the plus-maze discriminative avoidance task: role of state-dependent learning.

Authors:  C L Patti; S R Kameda; R C Carvalho; A L Takatsu-Coleman; G B Lopez; S T Niigaki; V C Abílio; R Frussa-Filho; R H Silva
Journal:  Psychopharmacology (Berl)       Date:  2005-12-10       Impact factor: 4.530

5.  Mu-opioid receptor splice variants: sex-dependent regulation by chronic morphine.

Authors:  Vittorio Verzillo; Priyanka A Madia; Nai-Jiang Liu; Sumita Chakrabarti; Alan R Gintzler
Journal:  J Neurochem       Date:  2014-06-11       Impact factor: 5.372

6.  Sex differences in locomotor effects of morphine in the rat.

Authors:  Rebecca M Craft; James L Clark; Stephen P Hart; Megan K Pinckney
Journal:  Pharmacol Biochem Behav       Date:  2007-01-09       Impact factor: 3.533

7.  Repeated Morphine Produces Sensitization to Reward and Tolerance to Antiallodynia in Male and Female Rats with Chemotherapy-Induced Neuropathy.

Authors:  L P Legakis; S S Negus
Journal:  J Pharmacol Exp Ther       Date:  2018-01-23       Impact factor: 4.030

8.  Entanglement between thermoregulation and nociception in the rat: the case of morphine.

Authors:  Nabil El Bitar; Bernard Pollin; Elias Karroum; Ivanne Pincedé; Daniel Le Bars
Journal:  J Neurophysiol       Date:  2016-09-07       Impact factor: 2.714

9.  Sex differences in the activation of the spinoparabrachial circuit by visceral pain.

Authors:  Anne Z Murphy; Shelby K Suckow; Malcolm Johns; Richard J Traub
Journal:  Physiol Behav       Date:  2009-03-09

10.  Sex specificity in methadone analgesia in the rat: a population pharmacokinetic and pharmacodynamic approach.

Authors:  Monica Rodriguez; M Angeles Carlos; Ignacio Ortega; Elena Suarez; Rosario Calvo; John C Lukas
Journal:  Pharm Res       Date:  2002-06       Impact factor: 4.200
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