Literature DB >> 9681139

Synthesis and inhibitory activity of novel tri- and tetracyclic quinolines against topoisomerases.

Z Sui1, J Altom, V N Nguyen, J Fernandez, J I Bernstein, J J Hiliard, J F Barrett, B L Podlogar, K A Ohemeng.   

Abstract

A series of isoindolo[2,1-a]- and pyrrolo[1,2-a]quinolines were designed and synthesized for DNA-gyrase and topoisomerase-II inhibition studies. Some of the compounds showed significant activity against the enzymes.

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Year:  1998        PMID: 9681139     DOI: 10.1016/s0968-0896(98)00030-3

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN: 0968-0896            Impact factor:   3.641


  7 in total

Review 1.  A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.

Authors:  Gregory S Bisacchi; Michael R Hale
Journal:  Curr Med Chem       Date:  2016       Impact factor: 4.530

2.  Convenient access to 5-arylisoindolo[2,1- α]quinolin-11(6a H)-ones.

Authors:  Melissa O'Brien; Rachael Weagle; Donald Corkum; Minati Kuanar; Prabhu P Mohapatra; Amitabh Jha
Journal:  Mol Divers       Date:  2017-01-05       Impact factor: 2.943

3.  Novel Schiff bases based on the quinolinone skeleton: syntheses, X-ray structures and fluorescent properties.

Authors:  Zdeněk Trávníček; Roman Buchtík; Ivan Nemec
Journal:  Molecules       Date:  2014-09-01       Impact factor: 4.411

4.  Synthesis, delivery, and molecular docking of fused quinolines as inhibitor of Hepatitis A virus 3C proteinase.

Authors:  Mehrnaz Rafiei Jorshari; Manouchehr Mamaghani; Parivash Jahanshahi
Journal:  Sci Rep       Date:  2021-09-23       Impact factor: 4.379

5.  Skeletal remodeling of chalcone-based pyridinium salts to access isoindoline polycycles and their bridged derivatives.

Authors:  Lele Wang; Huabin Han; Lijie Gu; Wenjing Zhang; Junwei Zhao; Qilin Wang
Journal:  Chem Sci       Date:  2021-11-09       Impact factor: 9.825

6.  Synthesis of dihydroisoindolo[2,1-a]quinolin-11-ones, their in silico ADMET properties and in vitro antitumor activities.

Authors:  Diego R Merchán-Arenas; Felipe Sojo; Francisco Arvelo; Vladimir V Kouznetsov
Journal:  RSC Adv       Date:  2020-11-19       Impact factor: 4.036

Review 7.  Advancements in the synthesis of fused tetracyclic quinoline derivatives.

Authors:  Ramadan A Mekheimer; Mariam A Al-Sheikh; Hanadi Y Medrasi; Kamal U Sadek
Journal:  RSC Adv       Date:  2020-05-27       Impact factor: 4.036

  7 in total

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