Literature DB >> 9679284

New derivatives of imidazole as potential anticancer agents.

I Krezel1.   

Abstract

A series of monocyclic amidinohydrazones 2a-h was prepared from the reaction of N-(4,5-dihydro-1H-imidazol-2-yl)-N-(2-hydroxy-ethyl) hydrazine hydroiodide 1 with various aromatic aldehydes. Some of them were subjected to an esterification with acetic anhydride to give 2a-d. Compounds 2a,c,d,e,f,h and 3c were tested for their anticancer and anti-HIV activity.

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Year:  1998        PMID: 9679284     DOI: 10.1016/s0014-827x(98)00031-7

Source DB:  PubMed          Journal:  Farmaco        ISSN: 0014-827X


  6 in total

1.  Pro-apoptotic activity of imidazole derivatives mediated by up-regulation of Bax and activation of CAD in Ehrlich Ascites Tumor cells.

Authors:  C Anil Kumar; Shankar Jayarama; Bharathi P Salimath; Kanchugarakoppal S Rangappa
Journal:  Invest New Drugs       Date:  2007-03-20       Impact factor: 3.850

2.  1-(3,5-Dimethyl-phen-yl)-4,5-dimethyl-2-phenyl-1H-imidazole hemihydrate.

Authors:  P Gayathri; A Thiruvalluvar; N Srinivasan; J Jayabharathi; R J Butcher
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-09

3.  3-(1H-Imidazol-1-yl)propanaminium 2-carb-oxy-4,6-di-nitro-phenolate.

Authors:  Thammarse S Yamuna; Manpreet Kaur; Brian J Anderson; Jerry P Jasinski; H S Yathirajan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-02-19

4.  Immune Stimulating Outcome of Chrysin and γ-Irradiation via Apoptotic Activation Against Solid Ehrlich Carcinoma Bearing Mice.

Authors:  Nermeen M El Bakary; Asmaa Z Alsharkawy; Zeinab A Shouaib; Emad M S Barakat
Journal:  Integr Cancer Ther       Date:  2022 Jan-Dec       Impact factor: 3.077

5.  2-[2-(4-Meth-oxy-phen-yl)-4,5-diphenyl-1H-imidazol-1-yl]ethanol.

Authors:  Shaaban Kamel Mohamed; Mehmet Akkurt; Adel A Marzouk; Vagif M Abbasov; Atash V Gurbanov
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-03-02

6.  3-(1H-Imidazol-1-yl)propanaminium picrate.

Authors:  T S Yamuna; Jerry P Jasinski; Courtney E Duff; H S Yathirajan; Manpreet Kaur
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-09-21
  6 in total

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