Literature DB >> 9679244

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

A Hata1, Y Shi, J Massagué.   

Abstract

Transforming growth factor-beta (TGF-beta) and related cytokines control the development and homeostasis of many tissues by regulating the expression of genes that determine cell phenotype. Recent progress has elucidated the way in which members of the TGF-beta family initiate their signal through transmembrane receptors and transmit it to target genes via the Smad family of signal-transducing proteins. This review describes TGF-beta signaling pathways as currently understood and mutations of the genes that encode Smads that disrupt the function of these proteins and cause various forms of cancer.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9679244     DOI： 10.1016/s1357-4310(98)01247-7

Source DB:  PubMed          Journal:  Mol Med Today        ISSN： 1357-4310


  33 in total

Review 1.  Structural determinants of Smad function in TGF-β signaling.

Authors:  Maria J Macias; Pau Martin-Malpartida; Joan Massagué
Journal:  Trends Biochem Sci       Date:  2015-04-29       Impact factor: 13.807

Review 2.  Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer.

Authors:  Barbara Jung; Jonas J Staudacher; Daniel Beauchamp
Journal:  Gastroenterology       Date:  2016-10-20       Impact factor: 22.682

3.  Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo.

Authors:  Claudia D Andl; Brenton B Fargnoli; Takaomi Okawa; Mark Bowser; Munenori Takaoka; Hiroshi Nakagawa; Andres Klein-Szanto; Xianxin Hua; Meenhard Herlyn; Anil K Rustgi
Journal:  Cancer Res       Date:  2006-10-15       Impact factor: 12.701

4.  Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway.

Authors:  J Xu; L Attisano
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

5.  Proteins involved in cutaneous basal cell carcinoma development.

Authors:  Magdalena Ciążyńska; Igor A Bednarski; Karolina Wódz; Paweł Kolano; Joanna Narbutt; Michał Sobjanek; Anna Woźniacka; Aleksandra Lesiak
Journal:  Oncol Lett       Date:  2018-07-11       Impact factor: 2.967

Review 6.  The tale of transforming growth factor-beta (TGFbeta) signaling: a soigné enigma.

Authors:  Arindam Chaudhury; Philip H Howe
Journal:  IUBMB Life       Date:  2009-10       Impact factor: 3.885

7.  Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements.

Authors:  T Rozovskaia; O Ravid-Amir; S Tillib; G Getz; E Feinstein; H Agrawal; A Nagler; E F Rappaport; I Issaeva; Y Matsuo; U R Kees; T Lapidot; F Lo Coco; R Foa; A Mazo; T Nakamura; C M Croce; G Cimino; E Domany; E Canaani
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-02       Impact factor: 11.205

Review 8.  The basics of epithelial-mesenchymal transition.

Authors:  Raghu Kalluri; Robert A Weinberg
Journal:  J Clin Invest       Date:  2009-06       Impact factor: 14.808

9.  TAK1 mRNA expression in the tumor tissue of locally advanced head and neck cancer patients.

Authors:  Beatriz Honorato; Juan Alcalde; Rafael Martinez-Monge; Natalia Zabalegui; Jesús Garcia-Foncillas
Journal:  Gene Regul Syst Bio       Date:  2008-02-14

10.  Transforming growth factor beta isoforms regulation of Akt activity and XIAP levels in rat endometrium during estrous cycle, in a model of pseudopregnancy and in cultured decidual cells.

Authors:  Pierre-Luc Caron; Guylaine Fréchette-Frigon; Carl Shooner; Valérie Leblanc; Eric Asselin
Journal:  Reprod Biol Endocrinol       Date:  2009-08-05       Impact factor: 5.211
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.