Literature DB >> 27773809

Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer.

Barbara Jung1, Jonas J Staudacher2, Daniel Beauchamp3.   

Abstract

Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.
Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Activin; Colon Cancer; Transforming Growth Factor β

Mesh：

Substances：

Year:  2016        PMID： 27773809      PMCID： PMC5550896          DOI： 10.1053/j.gastro.2016.10.015

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  199 in total

1.  Familial and sporadic primary pulmonary hypertension is caused by BMPR2 gene mutations resulting in haploinsufficiency of the bone morphogenetic protein tùype II receptor.

Authors:  J Thomson; R Machado; M Pauciulo; N Morgan; M Yacoub; P Corris; K McNeil; J Loyd; W Nichols; R Trembath
Journal:  J Heart Lung Transplant       Date:  2001-02       Impact factor: 10.247

2.  Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

Authors:  M Nishita; M K Hashimoto; S Ogata; M N Laurent; N Ueno; H Shibuya; K W Cho
Journal:  Nature       Date:  2000-02-17       Impact factor: 49.962

3.  TbetaR-I(6A) is a candidate tumor susceptibility allele.

Authors:  B Pasche; P Kolachana; K Nafa; J Satagopan; Y G Chen; R S Lo; D Brener; D Yang; L Kirstein; C Oddoux; H Ostrer; P Vineis; L Varesco; S Jhanwar; L Luzzatto; J Massagué; K Offit
Journal:  Cancer Res       Date:  1999-11-15       Impact factor: 12.701

Review 4.  The regulation and functions of activin and follistatin in inflammation and immunity.

Authors:  Mark P Hedger; Wendy R Winnall; David J Phillips; David M de Kretser
Journal:  Vitam Horm       Date:  2011       Impact factor: 3.421

5.  Role of transforming growth factor-beta signaling in cancer.

Authors:  M P de Caestecker; E Piek; A B Roberts
Journal:  J Natl Cancer Inst       Date:  2000-09-06       Impact factor: 13.506

6.  Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2.

Authors:  Noel F C C de Miranda; Maarten van Dinther; Brendy E W M van den Akker; Tom van Wezel; Peter ten Dijke; Hans Morreau
Journal:  Gastroenterology       Date:  2015-02-28       Impact factor: 22.682

Review 7.  Targeting the TGFβ signalling pathway in disease.

Authors:  Rosemary J Akhurst; Akiko Hata
Journal:  Nat Rev Drug Discov       Date:  2012-09-24       Impact factor: 84.694

8.  Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis.

Authors:  Yoshiro Itatani; Kenji Kawada; Teruaki Fujishita; Fumihiko Kakizaki; Hideyo Hirai; Takuya Matsumoto; Masayoshi Iwamoto; Susumu Inamoto; Etsuro Hatano; Suguru Hasegawa; Taira Maekawa; Shinji Uemoto; Yoshiharu Sakai; Makoto Mark Taketo
Journal:  Gastroenterology       Date:  2013-07-25       Impact factor: 22.682

9.  Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation.

Authors:  H Beppu; O N Mwizerwa; Y Beppu; M P Dattwyler; G Y Lauwers; K D Bloch; A M Goldstein
Journal:  Oncogene       Date:  2007-08-13       Impact factor: 9.867

Review 10.  Chronic inflammation and cytokines in the tumor microenvironment.

Authors:  Glauben Landskron; Marjorie De la Fuente; Peti Thuwajit; Chanitra Thuwajit; Marcela A Hermoso
Journal:  J Immunol Res       Date:  2014-05-13       Impact factor: 4.818
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  79 in total

Review 1.  MicroRNA regulation of liver cancer stem cells.

Authors:  Weiyang Lou; Jingxing Liu; Yanjia Gao; Guansheng Zhong; Bisha Ding; Liang Xu; Weimin Fan
Journal:  Am J Cancer Res       Date:  2018-07-01       Impact factor: 6.166

2.  Downregulation of DAPK1 promotes the stemness of cancer stem cells and EMT process by activating ZEB1 in colorectal cancer.

Authors:  Wenzheng Yuan; Jintong Ji; Yan Shu; Jinhuang Chen; Sanguang Liu; Liang Wu; Zili Zhou; Zhengyi Liu; Qiang Tang; Xudan Zhang; Xiaogang Shu
Journal:  J Mol Med (Berl)       Date:  2018-11-20       Impact factor: 4.599

3.  TGFBR1*6A is a potential modifier of migration and invasion in colorectal cancer cells.

Authors:  Rui Zhou; Ying Huang; Boran Cheng; Yulei Wang; Bin Xiong
Journal:  Oncol Lett       Date:  2018-01-04       Impact factor: 2.967

4.  CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes.

Authors:  Haruna Takeda; Shiho Kataoka; Mizuho Nakayama; Mohamed A E Ali; Hiroko Oshima; Daisuke Yamamoto; Jun-Won Park; Yujiro Takegami; Tadaichi An; Nancy A Jenkins; Neal G Copeland; Masanobu Oshima
Journal:  Proc Natl Acad Sci U S A       Date:  2019-07-12       Impact factor: 11.205

5.  Molecular Pathogenesis and Classification of Colorectal Carcinoma.

Authors:  Anup Kasi; Shivani Handa; Sajjad Bhatti; Shahid Umar; Ajay Bansal; Weijing Sun
Journal:  Curr Colorectal Cancer Rep       Date:  2020-08-15

6.  Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression.

Authors:  R J Seager; Cynthia Hajal; Fabian Spill; Roger D Kamm; Muhammad H Zaman
Journal:  Converg Sci Phys Oncol       Date:  2017-07-28

7.  TGFβ and activin A in the tumor microenvironment in colorectal cancer.

Authors:  Jasmin Zessner-Spitzenberg; Alexandra L Thomas; Nancy L Krett; Barbara Jung
Journal:  Gene Rep       Date:  2019-09-12

Review 8.  microRNAs and Corresponding Targets Involved in Metastasis of Colorectal Cancer in Preclinical In Vivo Models.

Authors:  Ulrich H Weidle; Ulrich Brinkmann; Simon Auslaender
Journal:  Cancer Genomics Proteomics       Date:  2020 Sep-Oct       Impact factor: 4.069

9.  Association of Body Mass Index With Colorectal Cancer Risk by Genome-Wide Variants.

Authors:  Peter T Campbell; Yi Lin; Stephanie A Bien; Jane C Figueiredo; Tabitha A Harrison; Mark A Guinter; Sonja I Berndt; Hermann Brenner; Andrew T Chan; Jenny Chang-Claude; Steven J Gallinger; Susan M Gapstur; Graham G Giles; Edward Giovannucci; Stephen B Gruber; Marc Gunter; Michael Hoffmeister; Eric J Jacobs; Mark A Jenkins; Loic Le Marchand; Li Li; John R McLaughlin; Neil Murphy; Roger L Milne; Polly A Newcomb; Christina Newton; Shuji Ogino; John D Potter; Gad Rennert; Hedy S Rennert; Jennifer Robinson; Lori C Sakoda; Martha L Slattery; Yiqing Song; Emily White; Michael O Woods; Graham Casey; Li Hsu; Ulrike Peters
Journal:  J Natl Cancer Inst       Date:  2021-01-04       Impact factor: 13.506

10.  The effect of CT26 tumor-derived TGF-β on the balance of tumor growth and immunity.

Authors:  Stephanie Y Owyang; Min Zhang; Grace A Walkup; Grace E Chen; Helmut Grasberger; Mohamad El-Zaatari; John Y Kao
Journal:  Immunol Lett       Date:  2017-10-03       Impact factor: 3.685
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