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Literature DB >> 9679056

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300.

Abstract

TGF-beta and activin induce the phosphorylation and activation of Smad2 and Smad3, but how these proteins stimulate gene transcription is poorly understood. We report that TGF-beta receptor phosphorylation of Smad3 promotes its interaction with the paralogous coactivators CBP and p300, whereas CBP/p300 binding to nonphosphorylated Smad3 or its oligomerization partner Smad4 is negatively regulated by Smad-intramolecular interactions. Furthermore, p300 and TGF-beta receptor-phosphorylated Smad3 synergistically augment transcriptional activation. Thus, CBP/p300 are important components of activin/TGF-beta signaling and may mediate the antioncogenic functions of Smad2 and Smad4.

Entities: Disease Gene Species

Mesh：

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Year: 1998 PMID： 9679056 PMCID： PMC317012 DOI： 10.1101/gad.12.14.2114

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

36 in total

1. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

Authors: R Eckner; M E Ewen; D Newsome; M Gerdes; J A DeCaprio; J B Lawrence; D M Livingston
Journal: Genes Dev Date: 1994-04-15 Impact factor: 11.361

2. The transcriptional coactivators p300 and CBP are histone acetyltransferases.

Authors: V V Ogryzko; R L Schiltz; V Russanova; B H Howard; Y Nakatani
Journal: Cell Date: 1996-11-29 Impact factor: 41.582

3. Steroid receptor coactivator-1 is a histone acetyltransferase.

Authors: T E Spencer; G Jenster; M M Burcin; C D Allis; J Zhou; C A Mizzen; N J McKenna; S A Onate; S Y Tsai; M J Tsai; B W O'Malley
Journal: Nature Date: 1997-09-11 Impact factor: 49.962

4. The adenovirus E1A-associated 300 kDa adaptor protein counteracts the inhibition of the collagenase promoter by E1A and represses transformation.

Authors: P H Smits; L de Wit; A J van der Eb; A Zantema
Journal: Oncogene Date: 1996-04-04 Impact factor: 9.867

5. p300 gene alterations in colorectal and gastric carcinomas.

Authors: M Muraoka; M Konishi; R Kikuchi-Yanoshita; K Tanaka; N Shitara; J M Chong; T Iwama; M Miyaki
Journal: Oncogene Date: 1996-04-04 Impact factor: 9.867

6. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

Authors: G Lagna; A Hata; A Hemmati-Brivanlou; J Massagué
Journal: Nature Date: 1996-10-31 Impact factor: 49.962

7. Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.

Authors: X Liu; Y Sun; S N Constantinescu; E Karam; R A Weinberg; H F Lodish
Journal: Proc Natl Acad Sci U S A Date: 1997-09-30 Impact factor: 11.205

Review 8. TGF-beta signalling from cell membrane to nucleus through SMAD proteins.

Authors: C H Heldin; K Miyazono; P ten Dijke
Journal: Nature Date: 1997-12-04 Impact factor: 49.962

9. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.

Authors: C Sirard; J L de la Pompa; A Elia; A Itie; C Mirtsos; A Cheung; S Hahn; A Wakeham; L Schwartz; S E Kern; J Rossant; T W Mak
Journal: Genes Dev Date: 1998-01-01 Impact factor: 11.361

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300.

1. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

2. The transcriptional coactivators p300 and CBP are histone acetyltransferases.

3. Steroid receptor coactivator-1 is a histone acetyltransferase.

4. The adenovirus E1A-associated 300 kDa adaptor protein counteracts the inhibition of the collagenase promoter by E1A and represses transformation.

5. p300 gene alterations in colorectal and gastric carcinomas.

6. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

7. Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.

Review 8. TGF-beta signalling from cell membrane to nucleus through SMAD proteins.

9. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.

10. Phosphorylated CREB binds specifically to the nuclear protein CBP.

Review 1. Transcriptional control by the TGF-beta/Smad signaling system.

2. A function of CBP as a transcriptional co-activator during Dpp signalling.

3. A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.

4. Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor beta signaling.

5. Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB.

6. Smads bind directly to the Jun family of AP-1 transcription factors.

7. Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins.

8. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling.

9. Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.

10. G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation.