Literature DB >> 9679020

Going the distance: a current view of enhancer action.

E M Blackwood1, J T Kadonaga.   

Abstract

In eukaryotes, transcription of genes by RNA polymerase II yields messenger RNA intermediates from which protein products are synthesized. Transcriptional enhancers are discrete DNA elements that contain specific sequence motifs with which DNA-binding proteins interact and transmit molecular signals to genes. Here, current models regarding the role of enhancers in the regulation of transcription by RNA polymerase II are presented.

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Year:  1998        PMID： 9679020     DOI： 10.1126/science.281.5373.60

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  288 in total

1.  Remodeling of yeast CUP1 chromatin involves activator-dependent repositioning of nucleosomes over the entire gene and flanking sequences.

Authors:  C H Shen; B P Leblanc; J A Alfieri; D J Clark
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

2.  Random, asynchronous, and asymmetric transcriptional activity of enhancer-flanking major immediate-early genes ie1/3 and ie2 during murine cytomegalovirus latency in the lungs.

Authors:  N K Grzimek; D Dreis; S Schmalz; M J Reddehase
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

3.  Multiple layers of cooperativity regulate enhanceosome-responsive RNA polymerase II transcription complex assembly.

Authors:  K Ellwood; W Huang; R Johnson; M Carey
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

4.  HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology.

Authors:  R Bagga; S Michalowski; R Sabnis; J D Griffith; B M Emerson
Journal:  Nucleic Acids Res       Date:  2000-07-01       Impact factor: 16.971

5.  Action of prokaryotic enhancer over a distance does not require continued presence of promoter-bound sigma54 subunit.

Authors:  Vladimir Bondarenko; Ye Liu; Alexander Ninfa; Vasily M Studitsky
Journal:  Nucleic Acids Res       Date:  2002-02-01       Impact factor: 16.971

6.  Deciphering genetic regulatory codes: a challenge for functional genomics.

Authors:  Alan M Michelson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-22       Impact factor: 11.205

7.  Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes.

Authors:  Ran Taube; Xin Lin; Dan Irwin; Koh Fujinaga; B Matija Peterlin
Journal:  Mol Cell Biol       Date:  2002-01       Impact factor: 4.272

8.  GAGA can mediate enhancer function in trans by linking two separate DNA molecules.

Authors:  Tokameh Mahmoudi; Katerina R Katsani; C Peter Verrijzer
Journal:  EMBO J       Date:  2002-04-02       Impact factor: 11.598

9.  Enhancer-promoter specificity mediated by DPE or TATA core promoter motifs.

Authors:  J E Butler; J T Kadonaga
Journal:  Genes Dev       Date:  2001-10-01       Impact factor: 11.361

Review 10.  Genetic dangers in poly(A) signals.

Authors:  N J Proudfoot
Journal:  EMBO Rep       Date:  2001-10       Impact factor: 8.807
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