Literature DB >> 9678347

X-chromosome inactivation: a repeat hypothesis.

M F Lyon1.   

Abstract

Recent work has shown that X-chromosome inactivation is brought about by Xist mRNA, which coats the inactive X-chromosome. This paper presents a hypothesis on the function of this RNA. It is suggested that interspersed repetitive elements of the LINE type, in which the X-chromosome is particularly rich, act as booster elements to promote the spread of Xist mRNA. Contact with this RNA causes the LINE elements to be sensed as repeated elements by the cell's system for repeat-induced gene silencing. This leads to the silencing of these elements and the intervening unique sequences by their conversion to heterochromatin.

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Year:  1998        PMID： 9678347     DOI： 10.1159/000014969

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  160 in total

1.  LINE-1 elements and X chromosome inactivation: a function for "junk" DNA?

Authors:  M F Lyon
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

2.  Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: the Lyon repeat hypothesis.

Authors:  J A Bailey; L Carrel; A Chakravarti; E E Eichler
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

3.  Xist yeast artificial chromosome transgenes function as X-inactivation centers only in multicopy arrays and not as single copies.

Authors:  E Heard; F Mongelard; D Arnaud; P Avner
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

4.  Absence of Z-chromosome inactivation for five genes in male chickens.

Authors:  Y Kuroda; N Arai; M Arita; M Teranishi; T Hori; M Harata; S Mizuno
Journal:  Chromosome Res       Date:  2001       Impact factor: 5.239

5.  Genomic anatomy of a premier major histocompatibility complex paralogous region on chromosome 1q21-q22.

Authors:  T Shiina; A Ando; Y Suto; F Kasai; A Shigenari; N Takishima; E Kikkawa; K Iwata; Y Kuwano; Y Kitamura; Y Matsuzawa; K Sano; M Nogami; H Kawata; S Li; Y Fukuzumi; M Yamazaki; H Tashiro; G Tamiya; A Kohda; K Okumura; T Ikemura; E Soeda; N Mizuki; M Kimura; S Bahram; H Inoko
Journal:  Genome Res       Date:  2001-05       Impact factor: 9.043

6.  Painting of fourth, a chromosome-specific protein in Drosophila.

Authors:  J Larsson; J D Chen; V Rasheva; A Rasmuson-Lestander; V Pirrotta
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

7.  Comparative analysis of the primate X-inactivation center region and reconstruction of the ancestral primate XIST locus.

Authors:  Julie E Horvath; Christina B Sheedy; Stephanie L Merrett; Abdoulaye Banire Diallo; David L Swofford; Eric D Green; Huntington F Willard
Journal:  Genome Res       Date:  2011-04-25       Impact factor: 9.043

8.  A Functional chromatin domain does not resist X chromosome inactivation: silencing of cLys correlates with methylation of a dual promoter-replication origin.

Authors:  Suyinn Chong; Joanna Kontaraki; Constanze Bonifer; Arthur D Riggs
Journal:  Mol Cell Biol       Date:  2002-07       Impact factor: 4.272

9.  Stable C0T-1 repeat RNA is abundant and is associated with euchromatic interphase chromosomes.

Authors:  Lisa L Hall; Dawn M Carone; Alvin V Gomez; Heather J Kolpa; Meg Byron; Nitish Mehta; Frank O Fackelmayer; Jeanne B Lawrence
Journal:  Cell       Date:  2014-02-27       Impact factor: 41.582

10.  Molecular control of the oocyte to embryo transition.

Authors:  Barbara B Knowles; Alexei V Evsikov; Wilhelmine N de Vries; Anne E Peaston; Davor Solter
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2003-08-29       Impact factor: 6.237
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