Literature DB >> 9671776

Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.

Y T Zhou1, M Shimabukuro, M Y Wang, Y Lee, M Higa, J L Milburn, C B Newgard, R H Unger.   

Abstract

Expression of peroxisome proliferator-activated receptor alpha (PPARalpha) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPARalpha/retinoid x receptor ligands, and FA all up-regulate PPARalpha and enzymes of FA oxidation and stimulate [3H]-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPARalpha is a OB-R-dependent factor required for normal fat homeostasis in islet cells.

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Year:  1998        PMID： 9671776      PMCID： PMC21174          DOI： 10.1073/pnas.95.15.8898

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  42 in total

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