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Literature DB >> 7004962

Preliminary characterization of calcium binding in islet-cell plasma membranes.

S P Naber, J M McDonald, L Jarett, M L McDaniel, C W Ludvigsen, P E Lacy.

Abstract

Preliminary characterization of calcium binding was determined in a highly-enriched islet-cell plasma membrane fraction using a membrane filtration technique. Equilbrium calcium binding was specific, concentration dependent and saturable. Scatchard analysis indicated the existence of more than one class of calcium binding sites. The affinity constants and maximum binding capacities were 1.14 X 10(5) M-1 and 1.2 picomol/microgram protein and 1.17 X 10(3) M-1 and 64.8 picomol/microgram for the high and low affinity sites, respectively. Bound 45Ca2+ was dissociate from the plasma membranes in a biphasic manner in the presence of excess unlabelled calcium.

Entities: Chemical

Mesh：

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Year: 1980 PMID： 7004962 DOI： 10.1007/bf00281823

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

31 in total

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