Literature DB >> 9671693

The elusive function of metallothioneins.

R D Palmiter1.   

Abstract

Biochemistry and genetics are both required to elucidate the function of macromolecules. There is no question that metallothioneins (MTs) have unique biochemical properties, but genetic experiments have not substantiated the importance of MTs under physiological conditions. Even after thousands of studies describing the structure, biochemical characteristics, tissue distribution, induction, and consequences of genetic disruption and deliberate overexpression, the evolutionary forces that led to the initial appearance, gene duplications, and nearly ubiquitous expression of MTs remain enigmatic.

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Year:  1998        PMID： 9671693      PMCID： PMC33872          DOI： 10.1073/pnas.95.15.8428

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  47 in total

1.  Ligand substitution and sulfhydryl reactivity of metallothionein.

Authors:  C F Shaw; M M Savas; D H Petering
Journal:  Methods Enzymol       Date:  1991       Impact factor: 1.600

Review 2.  Thinking about genetic redundancy.

Authors:  J H Thomas
Journal:  Trends Genet       Date:  1993-11       Impact factor: 11.639

3.  Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1.

Authors:  R D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

Review 4.  Metal-regulated transcription in eukaryotes.

Authors:  D J Thiele
Journal:  Nucleic Acids Res       Date:  1992-03-25       Impact factor: 16.971

5.  Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

Authors:  B A Masters; E J Kelly; C J Quaife; R L Brinster; R D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

6.  Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange.

Authors:  W Maret
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-04       Impact factor: 11.205

7.  Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse.

Authors:  A E Michalska; K H Choo
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

8.  Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.

Authors:  K T Tamai; E B Gralla; L M Ellerby; J S Valentine; D J Thiele
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

9.  Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles.

Authors:  B A Masters; C J Quaife; J C Erickson; E J Kelly; G J Froelick; B P Zambrowicz; R L Brinster; R D Palmiter
Journal:  J Neurosci       Date:  1994-10       Impact factor: 6.167

10.  Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia.

Authors:  C J Quaife; S D Findley; J C Erickson; G J Froelick; E J Kelly; B P Zambrowicz; R D Palmiter
Journal:  Biochemistry       Date:  1994-06-14       Impact factor: 3.162
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  144 in total

1.  Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein.

Authors:  L L Pearce; R E Gandley; W Han; K Wasserloos; M Stitt; A J Kanai; M K McLaughlin; B R Pitt; E S Levitan
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

2.  CNS wound healing is severely depressed in metallothionein I- and II-deficient mice.

Authors:  M Penkowa; J Carrasco; M Giralt; T Moos; J Hidalgo
Journal:  J Neurosci       Date:  1999-04-01       Impact factor: 6.167

3.  The crystal structure of yeast copper thionein: the solution of a long-lasting enigma.

Authors:  Vito Calderone; Benedikt Dolderer; Hans-Juergen Hartmann; Hartmut Echner; Claudio Luchinat; Cristina Del Bianco; Stefano Mangani; Ulrich Weser
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-21       Impact factor: 11.205

Review 4.  Metals in the "omics" world: copper homeostasis and cytochrome c oxidase assembly in a new light.

Authors:  Ivano Bertini; Gabriele Cavallaro
Journal:  J Biol Inorg Chem       Date:  2007-11-07       Impact factor: 3.358

5.  Further insights into the metal ion binding abilities and the metalation pathway of a plant metallothionein from Musa acuminata.

Authors:  Augusto C S Cabral; Jovana Jakovleska; Aniruddha Deb; James E Penner-Hahn; Vincent L Pecoraro; Eva Freisinger
Journal:  J Biol Inorg Chem       Date:  2017-12-07       Impact factor: 3.358

Review 6.  Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease.

Authors:  Alla V Glushchenko; Donald W Jacobsen
Journal:  Antioxid Redox Signal       Date:  2007-11       Impact factor: 8.401

7.  Heterologous expression and metal-binding characterization of a type 1 metallothionein isoform (OsMTI-1b) from rice (Oryza sativa).

Authors:  Rezvan Mohammadi Nezhad; Azar Shahpiri; Aghafakhr Mirlohi
Journal:  Protein J       Date:  2013-02       Impact factor: 2.371

8.  Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy.

Authors:  Liuchun Yang; Reagan McRae; Maged M Henary; Raxit Patel; Barry Lai; Stefan Vogt; Christoph J Fahrni
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-01       Impact factor: 11.205

9.  Zinc-gene interaction related to inflammatory/immune response in ageing.

Authors:  Eugenio Mocchegiani; Marco Malavolta
Journal:  Genes Nutr       Date:  2008-07       Impact factor: 5.523

10.  Influence of NH-Sgamma bonding interactions on the structure and dynamics of metallothioneins.

Authors:  Núria Romero-Isart; Baldo Oliva; Milan Vasák
Journal:  J Mol Model       Date:  2009-07-16       Impact factor: 1.810
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